In vitro Study of Biphasic Calcium Magnesium Phosphate Microspheres for Angiogenesis and Bone Formation

Wei WU; Shahd BAKHET; Naomi Addai ASANTE; Shefiu KAREEM; Omar Ramadhan KOMBO; Binbin LI; Honglian DAI

doi:10.15541/jim20220662

[1] K NARITA, E KOBAYASHI, TJMT SATO. Sintering behavior and mechanical properties of magnesium/β-tricalcium phosphate composites sintered by spark plasma sintering. Materials Transactions, 1620(2016).

[2] M CHUTHATHIP, M N AHMAD-FAUZI, B I YANNY-MARLIANA et al. Effect of magnesium oxide on physical and biological properties in β-tricalcium phosphate ceramic. Journal of Physics Conference Series, 012026(2018).

[3] S BASU, B BASU. Doped biphasic calcium phosphate: synthesis and structure. Journal of Asian Ceramic Societies, 265(2019).

[4] C D GHIȚULICĂ, A CUCURUZ, G VOICU et al. Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration. International Journal of Applied Ceramic Technology, 342(2020).

[5] K MAJI, S DASGUPTA. Effect of β-tricalcium phosphate nanoparticles additions on the properties of gelatin-chitosan scaffolds. Bioceramics Development & Applications, 1000103(2017).

[6] S MURAKAMI, H MIYAJI, E NISHIDA et al. Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds. Dental Materials Journal, 573(2017).

[7] Z Z FANG. Sintering of advanced materials, 85.

[8] I KAUR, L J ELLIS, I ROMER et al. Dispersion of nanomaterials in aqueous media: towards protocol optimization. Journal of Visualized Experiments, e56074(2017).

[9] W XUE, K DAHLQUIST, A BANERJEE et al. Synthesis and characterization of tricalcium phosphate with Zn and Mg based dopants. Journal of Materials Science: Materials in Medicine, 2669(2008).

[10] X GUO, Y LONG, W LI et al. Osteogenic effects of magnesium substitution in nano-structured β-tricalcium phosphate produced by microwave synthesis. Journal of Materials Science, 11197(2019).

[11] N ELIAZ, N J M METOKI. Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications. Materials, 334(2017).

[12] R R RAO, H N ROOPA, T S KANNAN. Solid state synthesis and thermal stability of HAP and HAP-β-TCP composite ceramic powders. Journal of Materials Science: Materials in Medicine, 511(1997).

[13] C RUIZ-AGUILAR, U OLIVARES-PINTO, E A AGUILAR-REYES et al. Characterization of β-tricalcium phosphate powders synthesized by Sol-Gel and mechanosynthesis. Boletín de la Sociedad Española de Cerámica y Vidrio, 213(2018).

[14] J ANDO. Tricalcium phosphate and its variation. Bulletin of the Chemical Society of Japan, 196(1958).

[15] M OLSSON. Chemical stability of grain boundariesinβ-tricalcium phosphate ceramics: β-TCP as bone substitute material. Department of Chemistry-Ångström, 42586904(2012).

[16] VM SGLAVO, M FRASNELLI. Effect of Mg²⁺ doping on beta- alpha phase transition in tricalcium phosphate (TCP) bioceramics. Acta Biomaterialia, 283(2016).

[17] Y MA, H DAI, X HUANG et al. 3D printing of bioglass-reinforced β-TCP porous bioceramic scaffolds. Journal of Materials Science, 10437(2019).

[18] M GALLO, B L G SANTONI, T DOUILLARD et al. Effect of grain orientation and magnesium doping on β-tricalcium phosphate resorption behavior. Acta Biomaterialia, 391(2019).

[19] D D S TAVARES, L D O CASTRO, G D D A SOARES et al. Synthesis and cytotoxicity evaluation of granular magnesium substituted β-tricalcium phosphate. Journal of Applied Oral Science, 37(2013).

[20] D LEE, C SFEIR, P N J M S KUMTA et al. Novel in-situ synthesis and characterization of nanostructured magnesium substituted β-tricalcium phosphate (β-TCMP). Materials Science, 69(2009).

[21] J MARCHI, A DANTAS, P GREIL et al. Influence of Mg-substitution on the physicochemical properties of calcium phosphate powders. Materials Research Bulletin, 1040(2007).

[22] H-S RYU, KS HONG, J-K LEE et al. Magnesia-doped HA/β-TCP ceramics and evaluation of their biocompatibility. Biomaterials, 393(2004).

[23] X ZHANG, F JIANG, T GROTH et al. Preparation, characterization and mechanical performance of dense β-TCP ceramics with/ without magnesium substitution. Journal of Materials Science: Materials in Medicine, 3063(2008).

[24] K ONUMA, M J C IIJIMA. Nanoparticles in β-tricalcium phosphate substrate enhance modulation of structure and composition of an octacalcium phosphate grown layer. CrystEngComm, 6660(2017).

[25] M S SADER, R Z LEGEROS, G A SOARES. Human osteoblasts adhesion and proliferation on magnesium-substituted tricalcium phosphate dense tablets. Journal of Materials Science: Materials in Medicine, 521(2009).

[26] L C LIN, S J CHANG, S M KUO et al. Preparation and evaluation of β-TCP/polylactide microspheres as osteogenesis materials. Journal of Applied Polymer Science, 3210(2008).

[27] Z YUAN, P WEI, Y HUANG et al. Injectable PLGA microspheres with tunable magnesium ion release for promoting bone regeneration. Acta Biomaterialia., 294(2019).

[28] J WANG, J XU, C HOPKINS et al. Biodegradable magnesium ased implants in orthopedics: a general review and perspectives. Advanced Science, 201902443(2020).

[29] S LIN, G YANG, F JIANG et al. Bone regeneration: a magnesiumnriched 3D culture system that mimics the bone development microenvironment for vascularized bone regeneration. Advanced Science, 1900209(2019).

[30] C PAN, X SUN, G XU et al. The effects of β-TCP on mechanical properties, corrosion behavior and biocompatibility of beta- TCP/Zn-Mg composites. Materials Science & Engineering C, 110397(2020).

[31] H ZHANG, Y SHEN, Y XIONG et al. Microstructural, mechanical properties and strengthening mechanism of DLP produced β-tricalcium phosphate scaffolds by incorporation of MgO/ZnO/58S bioglass. Ceramics International, 25863(2021).

[32] J ZHANG, L TANG, H QI et al. Dual function of magnesium in bone biomineralization. Advanced Healthcare Materials, 1901030(2019).

[33] X LIN, J GE, D WEI et al. Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium- modified acrylic bone cement. Journal of Orthopaedic Translation., 121(2019).

[34] F HE, Y TIAN, X FANG et al. Porous calcium phosphate composite bioceramic beads. Ceramics International, 13430(2018).

[35] V H HO, G TRIPATHI, J GWON et al. Novel TOCNF reinforced injectable alginate/β-tricalcium phosphate microspheres for bone regeneration. Materials & Design, 108892(2020).

[36] M MURAKAMI, L T NGUYEN, K HATANAKA et al. FGF-dependent regulation of VEGF receptor 2 expression in mice. The Journal of Clinical Investigation, 2668(2011).

[37] R OLIVARES-NAVARRETE, S L HYZY, R A GITTENS et al. Rough titanium alloys regulate osteoblast production of angiogenic factors. The Spine Journal, 1563(2013).

[38] P N MATKAR, R ARIYAGUNARAJAH, H LEONG-POI et al. Friends turned foes: angiogenic growth factors beyond angiogenesis. Biomolecules, 74(2017).

[39] S M CHIM, J TICKNER, S T CHOW et al. Angiogenic factors in bone local environment. Cytokine Growth Factor Reviews, 297(2013).

[40] A W TAN, L L LIAU, K H CHUA et al. Enhanced in vitro angiogenic behaviour of human umbilical vein endothelial cells on thermally oxidized TiO₂ nanofibrous surfaces. Scientific Reports, 21828(2016).

[41] M PRZYBYLSKI. A review of the current research on the role of bFGF and VEGF in angiogenesis. Journal of Wound Care, 516(2009).

[42] Y CHEN, Y OU, J DONG et al. Osteopontin promotes collagen I synthesis in hepatic stellate cells by miRNA-129-5p inhibition. Experimental Cell Research, 343(2017).

[43] B BHASKAR, R OWEN, H BAHMAEE et al. Composite porous scaffold of PEG/PLA support improved bone matrix deposition in vitro compared to PLA-only scaffolds. Journal of Biomedical Research Part A, 1334(2018).