A novel ZnO photoanode with high specific surface area and good light scattering ability was fabricated for dye-sensitized solar cells(DSSCs). The photoanode comprised of mesoporous ZnO microspheres which were prepared by a solvothermal process. The structures and morphologies of ZnO microspheres were measured and confirmed by means of x-ray diffraction(XRD), scanning electron microscopy(SEM), energy dispersive spectrum(EDS), and multi-point Brunauer-Emmett-Teller(BET) analysis. ZnO microspheres are in sub-micrometer scale and have BET specific surface area of ~50m2·g-1. Furthermore, a~3μm thick photoanode made from ZnO microspheres resultes in a preliminary short-circuit current density(Jsc) of ~45mA·cm-2 with an open-circuit voltage(Voc) of ~602mV and a conversion efficiency of 128% in DSSCs. All these suggest that mesoporous ZnO microspheres can be an alternative and feasible photoanode material for DSSCs.