Observations of intracellular second-harmonic generation imaging in black phosphorus nanosheets

Xiao Peng; Yiwan Song; Zheng Peng; Kaixuan Nie; Hao Liu; Yingxin Zhou; Feifan Zhou; Yufeng Yuan*; Jun Song; Junle Qu

doi:10.1142/s1793545820410060

[1] H. Li, J. Yu, R. Zhang et al., "Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors," J. Innov. Opt. Heal. Sci. 12, 1930009 (2019).

[2] C. Li, R. K. Pastila, C. P. Lin, "Label-free imaging immune cells and collagen in atherosclerosis with two-photon and second harmonic generation microscopy," J. Innov. Opt. Heal. Sci. 9, 1640003 (2015).

[3] Y. R. Shen, "Surface properties probed by secondharmonic and sum-frequency generation," Nature 337, 519–525 (1989).

[4] Y. Wang, J. Xiao, S. Yang et al., "Second harmonic generation spectroscopy on two-dimensional materials [Invited]," Opt. Mater. Exp. 9, 1136–1149 (2019).

[5] J. J. Dean, H. M. van Driel, "Graphene and fewlayer graphite probed by second-harmonic generation: Theory and experiment," Phys. Rev. B 82, 125411 (2010).

[6] Y. W. Shan, Y. G. Li, D. Huang et al., "Stacking symmetry governed second-harmonic generation in graphene trilayers," Sci. Adv. 4, eaat0074 (2018).

[7] Y. Zhang, D. Huang, Y. W. Shan et al., "Dopinginduced second-harmonic generation in centrosymmetric graphene from quadrupole response," Phys. Rev. Lett. 122, 047401 (2019).

[8] Y. L. Li, Y. Rao, K. F. Mak et al., "Probing symmetry properties of few-layer MoS2 and h-BN by optical second-harmonic generation," Nano Lett. 13, 3329–3333 (2013).

[9] S. Kim, J. E. Froch, A. Gardner et al., "Secondharmonic generation in multilayer hexagonal boron nitride flakes," Opt. Lett. 44, 5792–5795 (2019).

[10] X. B. Yin, Z. L. Ye, D. A. Chenet et al., "Edge nonlinear optics on a MoS2 atomic monolayer," Science 344, 488–490 (2014).

[11] G. Wang, X. Marie, I. Gerber et al., "Giant enhancement of the optical second-harmonic emission of WSe2 monolayers by laser excitation at exciton resonances," Phys. Rev. Lett. 114, 097403 (2015).

[12] K. L. Seyler, J. R. Schaibley, P. Gong et al., "Electrical control of second-harmonic generation in a WSe2 monolayer transistor," Nat. Nanotech. 10, 407–411 (2015).

[13] H. Weichun, M. Chunyang, L. Chao et al., "Highly stable MXene (V2CTx)-based harmonic pulse generation," Nanophoton. 9, 2577–2585 (2020).

[14] W. Y. Lei, G. Liu, J. Zhang et al., "Black phosphorus nanostructures: Recent advances in hybridization, doping and functionalization," Chem. Soc. Rev. 46, 3492–3509 (2017).

[15] J. L. Zhao, J. J. Zhu, R. Cao et al., "Liquefaction of water on the surface of anisotropic two-dimensional atomic layered black phosphorus," Nat. Commun. 10, 4062 (2019).

[16] Y. F. Yuan, X. T. Yu, Q. L. Ouyang et al., "Highly anisotropic black phosphorous-graphene hybrid architecture for ultrassensitive plasmonic biosensing: Theoretical insight," 2D Mater. 5, 025015 (2018).

[17] X. Chen, J. S. Ponraj, D. Y. Fan et al., "An overview of the optical properties and applications of black phosphorus," Nanoscale 12, 3513–3534 (2020).

[18] F. Hipolito, T. G. Pedersen, "Optical third harmonic generation in black phosphorus," Phys. Rev. B 97, 035431 (2018).

[19] R. L. Zhou, J. Peng, S. Yang et al., "Lifetime and nonlinearity of modulated surface plasmon for black phosphorus sensing application," Nanoscale 10, 18878–18891 (2018).

[20] H.-Y. Wu, Y. Yen, C.-H. Liu, "Observation of polarization and thickness dependent third-harmonic generation in multilayer black phosphorus," Appl. Phys. Lett. 109, 261902 (2016).

[21] M. J. L. F. Rodrigues, C. J. S. de Matos, Y. W. Ho et al., "Resonantly increased optical frequency conversion in atomically thin black phosphorus," Adv. Mater. 28, 10693–10700 (2016).

[22] N. Youngblood, R. Peng, A. Nemilentsau et al., "Layer-tunable third-harmonic generation in multilayer black phosphorus," ACS Photon. 4, 8–14 (2017).

[23] A. Autere, C. R. Ryder, A. S?yn?tjoki et al., "Rapid and large-area characterization of exfoliated black phosphorus using third-harmonic generation microscopy," J. Phys. Chem. Lett. 8, 1343–1350 (2017).

[24] Z. Xie, T. Fan, J. An et al., "Emerging combination strategies with phototherapy in cancer nanomedicine," Chem. Soc. Rev. doi: 10.1039/ D0CS00215A (2020).

[25] S. Xiong, X. Chen, Y. Liu et al., "Black phosphorus as a versatile nanoplatform: From unique properties to biomedical applications," J. Innov. Opt. Heal. Sci. 13, 2030008 (2020).

[26] J. D. Shao, H. H. Xie, H. Huang et al., "Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy," Nat. Commun. 7, 12967 (2016).

[27] M. Qiu, D. Wang, W. Y. Liang et al., "Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy," Proc. Natl. Acad. Sci. USA 115, 501–506 (2018).

[28] C. Xing, S. Chen, M. Qiu et al., "Conceptually novel black phosphorus/cellulose hydrogels as promising photothermal agents for effective cancer therapy," Nat. Commun. 7, 1701510 (2018).

[29] X. Liang, X. Ye, C. Wang et al., "Photothermal cancer immunotherapy by erythrocyte membranecoated black phosphorus formulation," J. Control. Release 296, 150–161 (2019).

[30] D. An, J. Fu, Z. Xie et al., "Progress in the therapeutic applications of polymer-decorated black phosphorus and black phosphorus analog nanomaterials in biomedicine," J. Mater. Chem. B 8, 7076– 7120 (2020).

[31] H. Hu, Z. Shi, K. Khan et al., "Recent advances in doping engineering of black phosphorus," J. Mater. Chem. A 8, 5421–5441 (2020).

[32] M. Qiu, A. Singh, D. Wang et al., "Biocompatible and biodegradable inorganic nanostructures for nanomedicine: Silicon and black phosphorus," Nano Today 25, 135–155 (2019).

[33] M. Qiu, W. X. Ren, T. Jeong et al., "Omnipotent phosphorene: A next-generation, two-dimensional nanoplatform for multidisciplinary biomedical applications," Chem. Soc. Rev. 47, 5588–5601 (2018).

[34] Z. B. Sun, H. H. Xie, S. Y. Tang et al., "Ultrasmall black phosphorus quantum dots: Synthesis and use as photothermal agents," Angew. Chem. Int. Edn. 54, 11526–11530 (2015).

[35] H. Liang, Z. Peng, X. Peng et al., "Fluorescence lifetime imaging microscopy (FLIM) monitors tumor cell death triggered by photothermal therapy with MoS2 nanosheets," J. Innov. Opt. Heal. Sci. 12, 1940002 (2019).

[36] L. L. Liang, W. Yan, X. Qin et al., "Designing sub- 2 nm organosilica nanohybrids for far-field superresolution imaging," Angew. Chem. Int. Edn. 59, 746–751 (2020).

[37] H. Li, S. Ye, J. Q. Guo et al., "Biocompatible carbon dots with low-saturation-intensity and highphotobleaching- resistance for STED nanoscopy imaging of the nucleolus and tunneling nanotubes in living cells," Nano Res. 12, 3075–3084 (2019).

[38] J. Zhao, D. Zhong, S. Zhou, "NIR-I-to-NIR-II fluorescent nanomaterials for biomedical imaging and cancer therapy," J. Mater. Chem. B 6, 349–365 (2018).

[39] A. Splendiani, L. Sun, Y. Zhang et al., "Emerging photoluminescence in monolayer MoS2," Nano Lett. 10, 1271–1275 (2010).

[40] A. Granados del Aguila, S. Liu, T. T. H. Do et al., "Linearly polarized luminescence of atomically thin MoS2 semiconductor nanocrystals," ACS Nano 13, 13006–13014 (2019).