Photonic crystal fiber laser has been attached great attention by many researches, and preparation of photonic crystal fiber cores becomes the key problem in study of photonic crystal fibers. Nd3+ doped lithium- cadmium heavy- metal silicate glass samples have prepared with the method of high temperature melting, which 40SiO2-14Al2O3-(40-x)CdO-2Li2O-2K2O-2Na2O-xNd2O3 (x=0.07, 0.14, 0.21, 0.35, 0.42, 0.56 mol) samples have been measured absorption and fluorescence spectra. Applying Judd- Ofelt theory, its intensity parameter Ωt(t=2, 4, 6), the oscillator strength and spontaneous radiation probability of the Nd3+ ion, fluorescence branching ratio, and the fluorescence lifetime were theoretically calculated. Using fluorescence spectrum, the stimulated emission cross section of the 4F3/2→4I11/2 transition and the full width at half maximum of the fluorescence band were also measured. The result demonstrates that the Nd3+ doped lithium-cadmium heavy-metal silicate glass sample When mixing Nd2O3 mole fraction of is 0.42 possesses a large stimulated emission cross section and a wide fluorescence band compared with the literature of neodymium ions doped glass. These parameters clearly indicate that this kind of silicate glass has a good laser excitation property and is expected to be applied in the study of the doped photonic crystal fibers.