A novel design of non-zero dispersion-shifted fiber and its fabrication by MCVD+OVD process are presented. An effective-area of greater than 71 μm2 is obtained for the designed fiber. Dispersion characteristics is improved by reducing 1550 nm dispersion slope from 0.0715 ps/(nm2·km) to 0.0605 ps/(nm2·km)or 0.0466 ps/(nm2·km),while zero dispersion wavelength was shifted from 1500 nm to 1450 nm. Experimental measurement indicates that the fabricated fiber has an excellent optical transmission property with a excellent macro-bending and splice performance,suitable for high-speed long haul dense wavelength division multiplexing systems in C+L or S+C+L bands. This innovative design procedure utilizes accurate perturbation algorithm for fine adjustment of key-part of fiber configuration,the method is not limited to MCVD process and non-zero dispersion-shifted fibers,but also can be applied for the development of specialty fibers.