A simple, flexible and stable frequency conversion approach based on a single optical frequency comb (OFC) is proposed. In this method, a dual-polarization quadrature phase shift keying modulator (DP-QPSK) is employed. The DP-QPSK is an integrate modulator which integrates two dual-parallel Mach-Zehnder modulators (DPMZM). One DPMZM is working as an OFC generator. Another is working as carrier suppressive single sideband modulator to generate single sideband signal. An orthogonal and coupled signal is output from this modulator. This signal is converted to a signal with fixed polarization angle under the control of polarization controller and the polarizer. After the signal is put into the photoelectric detector, the microwave signal is generated. The simulation results show that multi-band frequency conversion can be realized by properly adjusting six direct current (DC) bias points of the proposed integrate modulator and disjunctive phase shifter. For example, the signal at C band 3.8 GHz can be converted to X, Ku, K and Ka bands. The signal at X band 9.6 GHz can be down-converted to C band or up-converted to Ku, K, Ka bands. In addition, the system emerges a good adaption to the DC bias points drafting and has a good operability.