Currently 3D model animation has been widely used in film, television, games and other fields. The basic principle o 3D model animation is that the position of each vertex of the model will change in different time. It can be divided into Morph animation, Skeleton animation and Skinned Mesh animation. Skinned Mesh animation solves the problem of seams. And it is popular because of its realistic, flexible interaction effects. In the application background of three-dimensional e-learning platform, this article describes the principle of skinned mesh animation technology, and compares three kinds of key frame interpolation methods. We hope to improve the picture quality while increasing the run speed of Skinned Mesh animation. Meanwhile, the visual effects of the network teaching platform can be optimized.