Le PENG, Lu ZHOU, Yan-ping QING, Li-ying TONG, Zhao-heng LIANG, Hao FU, Jun ZHOU. High Sensitivity Detection of Gene-like Tumor Markers Based on SERS Characteristics of Hollow Sea-urchin Gold Nanoparticles and Noble Metal/semiconductor Substrate[J]. Acta Photonica Sinica, 2020, 49(8): 0817002
- Acta Photonica Sinica
- Vol. 49, Issue 8, 0817002 (2020)
Fig. 1. Construction of the sandwich structure detect platform and SERS-based bioassay protocol
Fig. 2. SEM and TEM images, EDS spectrum of HSU-GNPs, and the UV-vis absorption spectra of HSU-GNPs, HSU-GNPs@4-MBA and HSU-GNPs@4-MBA@5'-NH2-ssDNA probes.
Fig. 3. SEM images of the ZnO nano-pencil structure and Ag/ZnO nanostructure prepared at different magnetron sputtering time
Fig. 4. X-rays diffraction patterns of ZnO and Ag/ZnO substrates
Fig. 5. SERS spectra and the intensities of SERS peaks of 4-MBA attached on various Ag/ZnO nanostructures, ) Raman spectrum of 4-MBA powder (line a), SERS spectra of 4-MBA on the freshly prepared and saved Ag/ZnO (line b and c)
Fig. 6. SERS spectra of 4-MBA and the dose-response curves corresponding for the miRNA-106a samples
Fig. 7. SERS spectra corresponding to different analytes
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Table 1. Oligonucleotides sequences
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Table 2. Detection results of miRNA-106a
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