[1] Siegel R L, Miller K D, Jemal A. Cancer statistics, 2016［J］. CA: A Cancer Journal for Clinicians, 2016, 66(1): 7-30.
[2] National Bureau of Statistics of China. China statistical yearbook 2010［J］. Beijing: China Statics Press, 2010.
[3] Chen W Q, Zheng R S, Baade P D, et al. Cancer statistics in China, 2015［J］. CA: A Cancer Journal for Clinicians, 2016, 66(2): 115-132.
[4] Plaks V, Koopman C D, Werb Z. Circulating tumor cells［J］. Science, 2013, 341(6151): 1186-1188.
[5] Chaffer C L, Weinberg R A. A perspective on cancer cell metastasis［J］. Science, 2011, 331(6024): 1559-1564.
[6] Cristofanilli M, Budd G T, Ellis M J, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer［J］. New England Journal of Medicine, 2004, 351: 781-791.
[7] Cohen S J, Punt C J, Iannotti N, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer［J］. Journal of Clinical Oncology, 2008, 26(19): 3213-3221.
[8] de Bono J S, Scher H I, Montgomery R B, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer［J］. Clinical Cancer Research, 2008, 14(19): 6302-6309.
[9] Alix-Panabières C, Pantel K. Circulating tumor cells: liquid biopsy of cancer［J］. Clinical Chemistry, 2013, 59(1): 110-118.
[10] Galanzha E I, Zharov V P. Circulating tumor cell detection and capture by photoacoustic flow cytometry in vivo and ex vivo［J］. Cancers, 2013, 5(4): 1691-1738.
[11] Alix-Panabières C, Pantel K. Challenges in circulating tumour cell research［J］. Nature Reviews Cancer, 2014, 14(9): 623-631.
[12] Novak J, Georgakoudi I, Wei X, et al. In vivo flow cytometer for real-time detection and quantification of circulating cells［J］. Optics Letters, 2004, 29(1): 77-79.
[13] Ding Y, Wang J, Fan Z, et al. Signal and depth enhancement for in vivo flow cytometer measurement of ear skin by optical clearing agents［J］. Biomedical Optics Express, 2013, 4(11): 2518-2526.
[14] He W, Wang H, Hartmann L C, et al. In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry［J］. Proceedings of the National Academy of Sciences, 2007, 104(28): 11760-11765.
[15] Sigrist M W. Laser generation of acoustic waves in liquids and gases［J］. Journal of Applied Physics, 1986, 60(7): R83-R122.
[16] Viator J A, Goldschmidt B S, Bhattacharyya K, et al. Photoacoustic flow cytometry for detection and capture of circulating melanoma cells［M］//Circulating Tumor Cells: Isolation and Analysis. New Jersey: John Wiley & Sons, Incorporation, 2016: 249-266.
[17] Bell A G. On the production and reproduction of sound by light［J］. American Journal of Science, 2017, 20: 305-324.
[18] Zeng Guang, Shi Yan, Song Liang, et al. Novel illumination design of acoustic resolution photoacoustic microscopy system［J］. Chinese J Lasers, 2016, 43(2): 0204002.
[19] Hill D W, Powell T. Non-dispersive infra-red gas analysis in science, medicine, and industry［M］. ［S.l.］: Plenum Press, 1968.
[20] Rosencwaig A. Photoacoustic spectroscopy of solids［J］. Optics Communications, 1973, 7(4): 305-308.
[21] Mc Donald F A, Wetsel G C, Jr. Generalized theory of the photoacoustic effect［J］. Journal of Applied Physics, 1978, 49(4): 2313-2322.
[22] Ode H. Photoacoustic microscope for detecting reflected detection light resulting from modulation by specimen: US9335253［P］. 2016-05-10.
[23] Xu M, Wang L V. Photoacoustic imaging in biomedicine［J］. Review of Scientific Instruments, 2006, 77(4): 041101.
[24] Xu Dong, Xiang Liangzhong, Ji Xuanrong. Photoacoustic imaging system based on multi-channel parallel acquisition［J］. Chinese J Lasers, 2011, 38(2): 0204002.
[26] He G, Xu D, Qin H, et al. In vivo cell characteristic extraction and identification by photoacoustic flow cytography［J］. Biomedical Optics Express, 2015, 6(10): 3748-3756.
[27] Sarimollaoglu M, Nedosekin D A, Simanovsky Y, et al. In vivo photoacoustic time-of-flight velocity measurement of single cells and nanoparticles［J］. Optics Letters, 2011, 36(20): 4086-4088.
[28] Cai C, Nedosekin D A, Menyaev Y A, et al. Photoacoustic flow cytometry for single sickle cell detection in vitro and in vivo［J］. Analytical Cellular Pathology, 2016, 2016: 2642361.
[29] Menyaev Y A, Carey K A, Nedosekin D A, et al. Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery［J］. Biomedical Optics Express, 2016, 7(9): 3643-3658.
[30] Liu R, Wang C, Hu C, et al. In vivo, label-free, and noninvasive detection of melanoma metastasis by photoacoustic flow cytometry［C］. SPIE, 2014: 89440Q.
[31] Yang P, Liu R, Niu Z, et al. Noninvasive and label-free detection of circulating melanoma cells by in vivo photoacoustic flow cytometry［C］. SPIE, 2015: 93240G.
[32] Zharov V P, Galanzha E I, Shashkov E V, et al. In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents［J］. Optics Letters, 2006, 31(24): 3623-3625.
[33] Galanzha E I, Zharov V P. In vivo photoacoustic and photothermal cytometry for monitoring multiple blood rheology parameters［J］. Cytometry Part A, 2011, 79(10): 746-757.
[34] Galanzha E I, Shashkov E V, Spring P M, et al. In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laser［J］. Cancer Research, 2009, 69(20): 7926-7934.
[35] He Y, Wang L, Shi J, et al. In vivo label-free photoacoustic flow cytography and on-the-spot laser killing of single circulating melanoma cells［J］. Scientific Reports, 2016, 6: 39616.
[36] Oppenheim A V, Willsky A S, Nawab S H. Signals and systems［M］. New Jersey: Prentice-Hall Englewood Cliffs, 1983.
[37] Strohm E M, Berndl E S, Kolios M C. Probing red blood cell morphology using high-frequency photoacoustics［J］. Biophysical Journal, 2013, 105(1): 59-67.
[38] Strohm E M, Berndl E S, Kolios M C. High frequency label-free photoacoustic microscopy of single cells［J］. Photoacoustics, 2013, 1(3): 49-53.
[39] Strohm E M, BerndL E S, Kolios M C. Circulating tumor cell detection using photoacoustic spectral methods［C］. SPIE, 2014: 89430D.
[40] Niu Z, Yang P, Wei D, et al. Improving the signal analysis for in vivo photoacoustic flow cytometry［C］. SPIE, 2015: 932413.
[42] Galanzha E I, Kim J W, Zharov V P. Nanotechnology-based molecular photoacoustic and photothermal flow cytometry platform for in-vivo detection and killing of circulating cancer stem cells［J］. Journal of Biophotonics, 2009, 2(12): 725-735.
[43] Galanzha E I, Nedosekin D A, Sarimollaoglu M, et al. Photoacoustic and photothermal cytometry using photoswitchable proteins and nanoparticles with ultrasharp resonances［J］. Journal of Biophotonics, 2015, 8(1/2): 81-93.
[44] Nedosekin D A, Juratli M A, Sarimollaoglu M, et al. Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo［J］. Journal of Biophotonics, 2013, 6(6/7): 523-533.
[45] Shashkov E V, Galanzha E I, Zharov V P. Photothermal and photoacoustic Raman cytometry in vitro and in vivo［J］. Optics Express, 2010, 18(7): 6929-6944.
[46] Juratli M A, Sarimollaoglu M, Siegel E R, et al. Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry［J］. Head & Neck, 2014, 36(8): 1207-1215.
[47] Galanzha E I, Shashkov E, Sarimollaoglu M, et al. In vivo magnetic enrichment, photoacoustic diagnosis, and photothermal purging of infected blood using multifunctional gold and magnetic nanoparticles［J］. Plos One, 2012, 7(9): e45557.
[48] Galanzha E I, Kokoska M S, Shashkov E V, et al. In vivo fiber-based multicolor photoacoustic detection and photothermal purging of metastasis in sentinel lymph nodes targeted by nanoparticles［J］. Journal of Biophotonics, 2009, 2(8/9): 528-539.
[49] O′Brien C M, Rood K D, Bhattacharyya K, et al. Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow［J］. Journal of Biomedical Optics, 2012, 17(6): 061221.
[50] Nedosekin D A, Khodakovskaya M V, Biris A S, et al. In vivo plant flow cytometry: a first proof-of-concept［J］. Cytometry Part A, 2011, 79(10): 855-865.
[51] Nolan J, Sarimollaoglu M, Nedosekin D A, et al. In vivo flow cytometry of circulating tumor-associated exosomes［J］. Analytical Cellular Pathology, 2016, 2016: 1628057.
[52] Nedosekin D A, Sarimollaoglu M, Ye J H, et al. In vivo ultra-fast photoacoustic flow cytometry of circulating human melanoma cells using near-infrared high-pulse rate lasers［J］. Cytometry Part A, 2011, 79(10): 825-833.
[53] Juratli M A, Galanzha E I, Sarimollaoglu M, et al. In vivo detection of circulating tumor cells during tumor manipulation［C］. SPIE, 2013: 85652H.
[54] Sarimollaoglu M, Nedosekin D A, Menyaev Y A, et al. Nonlinear photoacoustic signal amplification from single targets in absorption background［J］. Photoacoustics, 2014, 2(1): 1-11.
[55] Kim J W, Galanzha E I, Shashkov E V, et al. Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents［J］. Nature Nanotechnology, 2009, 4(10): 688-694.
[56] Zharov V P, Galanzha E I, Shashkov E V, et al. Photoacoustic flow cytometry: principle and application for real-time detection of circulating single nanoparticles, pathogens, and contrast dyes in vivo［J］. Journal of Biomedical Optics, 2007, 12(5): 51503.
[57] Nedosekin D A, Sarimollaoglu M, Shashkov E V, et al. Ultra-fast photoacoustic flow cytometry with a 0.5 MHz pulse repetition rate nanosecond laser［J］. Optics Express, 2010, 18(8): 8605-8620.
[58] Galanzha E I, Shashkov E V, Kelly T, et al. In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells［J］. Nature Nanotechnology, 2009, 4(12): 855-860.
