Fig. 1. Structure and properties of the HCMW. (a) HCMW 3D schematic diagram. (b) The COMSOL simulation image of the HCMW. (c) The reflectivity simulation image of the HCMW with different imaginary parts of dielectric coefficient ε_i (from 0 to 1 × 10⁵).

Fig. 2. Variation of ox-LDL in different light fields. (a) and (b) Structures of LDL and ox-LDL, respectively. Meanwhile, the detailed components are described in Supplementary Materials. (c) HCMW 3D schematic diagram. (d) Quartz cuvette. (e) The ox-LDL, which is illuminated in the HCMW. (f) The ox-LDL, which is illuminated in the cuvette. (g) The experimental reflection spectra for ox-LDL with different time exposures to the laser in the HCMW. (h) The experimental reflection spectra for ox-LDL with different time exposures to the laser in the cuvette.

Fig. 3. ELISA experiment of ox-LDL after laser illumination. (a) Schematic illustration of ELISA experiment. (b) Optical density comparison of unilluminated ox-LDL and 40 min illuminated ox-LDL in the HCMW, respectively.

Fig. 4. Comparison of different experiment parameters. (a) The measured reflection spectra of the HCMW filled with different laser continuous irradiation time ox-LDL. (b) Image of ΔR with different laser irradiation time. (c) and (d) The measured reflection spectra of the HCMW filled with ox-LDL under the irradiation of 5 mW and 50 mW laser beams, respectively. (e) and (f) The measured reflection spectra of the HCMW filled with ox-LDL illuminated by 473 nm and 532 nm lasers, respectively.

Fig. 5. Analysis of ox-LDL structures variation after laser irradiation. (a) and (b) 1H NMR spectra of ox-LDL before laser irradiation and after 40 min irradiation in the HCMW, respectively. (c) and (d) Micro-IR spectra of ox-LDL before laser irradiation and after 40 min illumination in the HCMW, respectively. (e) and (f) Circular dichroism (CD) spectra of both states of ox-LDL in the HCMW, respectively: CD (black), HT (red), and absorption of solution (blue).

Fig. 6. (a) and (b) Experimental CD spectra (black), software simulation curves (red), and the difference between the measured CD spectra and software simulation curves (blue).

Table 1. Experiment Data of ox-LDL ELISA, Both Exposed and Unexposed