• Journal of Infrared and Millimeter Waves
  • Vol. 40, Issue 6, 784 (2021)
Juan-Juan FU, Jin-Lan TANG, Yi-Lin BAO, Hui SHANG, Jin-Jin WU, Xiao WANG, and Jian-Hua YIN*
Author Affiliations
  • Department of Biomedical Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing 211106,China
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    DOI: 10.11972/j.issn.1001-9014.2021.06.012 Cite this Article
    Juan-Juan FU, Jin-Lan TANG, Yi-Lin BAO, Hui SHANG, Jin-Jin WU, Xiao WANG, Jian-Hua YIN. Novel design of a NIR fiber optic probe for in situ detection of osteoarthritis[J]. Journal of Infrared and Millimeter Waves, 2021, 40(6): 784 Copy Citation Text show less
    Overall structure diagram of NIR fiber probe
    Fig. 1. Overall structure diagram of NIR fiber probe
    (a)Schematic diagrams of the top end of the exit and entrance optical fibers,(b)the end face arrangement of 6 exit optical fibers,(c)the end face arrangement of 13 incident optical fibers
    Fig. 2. (a)Schematic diagrams of the top end of the exit and entrance optical fibers,(b)the end face arrangement of 6 exit optical fibers,(c)the end face arrangement of 13 incident optical fibers
    Setting photo of NIR fiber probe coupled with FTNIR system
    Fig. 3. Setting photo of NIR fiber probe coupled with FTNIR system
    (a) Conventional transmission FTNIR spectra and optical fiber - FTNIR spectra of sucrose powder, (b) optical fiber -FTNIR spectra of sucrose powder by 10-time repeated measurement at same position
    Fig. 4. (a) Conventional transmission FTNIR spectra and optical fiber - FTNIR spectra of sucrose powder, (b) optical fiber -FTNIR spectra of sucrose powder by 10-time repeated measurement at same position
    Average in-situ NIR spectra of articular cartilage (Health and OA tissues) BC (a) and second derivative (2nd-3-25SG) (b)
    Fig. 5. Average in-situ NIR spectra of articular cartilage (Health and OA tissues) BC (a) and second derivative (2nd-3-25SG) (b)
    纤芯直径/mm涂覆层直径/mm光纤束与自聚焦透镜的距离/mm6根出射光纤出射端的总能量/W
    0.20.3200.533
    0.20.3220.285
    0.20.3250.011
    0.20.24500.566
    0.20.24520.294
    0.20.24550.012
    0.30.5200.733
    0.30.5220.552
    0.30.5250.103
    Table 1. The simulation results of gradient-index (grin) lens with different distances to the top of fiber bundle
    主成分波数/cm-1官能团

    胶原蛋白

    胶原蛋白

    胶原蛋白

    4 890

    4 610

    4 050

    N-H面内弯曲振动

    C-H反对称伸缩振动和变形振动

    蛋白分子的C-H组合和C-H-C对称伸缩震动的一级倍频

    多糖4 310C-H伸缩振动和 CH2 变形振动
    自由水6 890N-H、水伸缩振动的一级倍频和C=O伸缩振动的三级倍频
    自由水和结合水5 150O-H的伸缩振动和变形震动
    Table 2. The relationships between NIR spectral characteristic bands and main components, functional groups of articular cartilage [18]
    类别判别结果识别率识别率(总)
    健康OA
    初始案例健康27196.43%97.62%
    OA15598.21%
    交叉验证健康25389.29%90.47%
    OA55191.07%
    预测集健康140100%96.43%
    OA11392.86%
    Table 3. FDA results of in-situ NIR spectra of healthy and OA tissues after 1st -2-21SG pretreatment
    Juan-Juan FU, Jin-Lan TANG, Yi-Lin BAO, Hui SHANG, Jin-Jin WU, Xiao WANG, Jian-Hua YIN. Novel design of a NIR fiber optic probe for in situ detection of osteoarthritis[J]. Journal of Infrared and Millimeter Waves, 2021, 40(6): 784
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