A novel preform fabrication process for non-zero dispersion-shifted fibers using hybrid modified chemical vapor deposition (MCVD)+ vapor axial deposition (VAD) technique is presented. The new design concept of the hybrid process is based on the normalized waveguide structure of the fiber, whereby fabricating core preforms with homogeneous normalized waveguide using MCVD process and out-cladding using axis control technique via VAD process to realize a homogeneous waveguide along axis of the preform. The manufacturing process of non-zero dispersion-shifted fibers is experimentally studied and the results show that preforms with homogeneous waveguide are fabricated successfully, with effective use of the taper of the preforms to increase the preform length, achieving about 15% increase of fiber production efficiency and cost reduction. Three key procedures in the hybrid fabrication process are discussed in detail, including the fabrication of normalized structure, the initialization of constriction ratio of core preform and the soot deposition via VAD process. The results provide a useful guideline for practical fabrication of non-zero dispersion-shifted fibers.