The necessity to measure advanced glycation endproducts (AGE) was analyzed in the present paper,and the apparatus for measuring skin autofluorescence was also designed making use of the special excitation spectrum and emission spectrum. A portion of tissue at the volar side of the arm of individuals (11 diabetes and 19 control subjects) was illuminated with excitation light,i.e. monochromatic light around 370 nm,and the emission spectrum was detected on the skin of control subjects and diabetic patients respectively. All measurements were performed at room temperature in a semi-dark environment. It can be seen that different sites of an individual could lead to different results,and the color can also affect the results. The technology of fluorescence precorrection was applied in order to get rid of the influence of noise,different site of skin,the color of skin etc. The result indicates that the technology of precorrection is of avail and the repetitiveness is well.