Until now, multinational related color scientists have accumulated more than 40 color formula, but the current use of all the color difference formula can only be limited to the given observation conditions in the CIE. Solid-state lighting as the focus of recent years, the focus of research, related research, such as related research based on LED lighting conditions has not started yet. So in this experiment, following the CIE color of the guiding principle of the study, we first selected CIE recommended 17 color centers in the five colors, which were made of experimental color proofs, followed by U30, TL84, D65 standard light source was set as the reference light source, To LED light bulb as experimental light source. The CIE1976LUV color difference formula, CIE1976LAB color difference formula and CIEDE2000 color difference formula were used to calculate the color difference of the printed patches respectively. Then, 20 visual observers were used to evaluate the subjective color difference of the printed patches by the visual evaluation experiment based on psychophysics. Finally, the objective calculation residual value (STRESS) is used to compare the objective calculation value with the subjective evaluation data. Found in this test selected three color formula in the LED lighting conditions, the color prediction performance is not very satisfactory. Overall, in the LED lighting conditions, CIE1976LUV formula predictive performance is relatively better, followed by CIEDE2000 formula, CIE1976LAB formula the third.