• Chinese Journal of Quantum Electronics
  • Vol. 40, Issue 3, 319 (2023)
WANG Haiqing1,2 and SHI Wei1,*
Author Affiliations
  • 1Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology,Xi'an 710048, China
  • 2Baoji Key Laboratory of Micro-Nano Optoelectronics and Terahertz Technology, School of Physics andOpto-Electronic Technology, Baoji University of Arts and Sciences, Baoji 721016, China
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    DOI: 10.3969/j.issn.1007-5461.2023.03.003 Cite this Article
    Haiqing WANG, Wei SHI. Research progress of THz-ATR technology for detecting biomedical samples[J]. Chinese Journal of Quantum Electronics, 2023, 40(3): 319 Copy Citation Text show less
    Schematic diagram of evanescent wave generated by ATR prism
    Fig. 1. Schematic diagram of evanescent wave generated by ATR prism
    (a) Verification model of milk fat, total solid and somatic cells[29] ; (b) THz spectra of glucose solutions with different concentrations and scatter plot between actual and predicted glucose concentrations[30]
    Fig. 2. (a) Verification model of milk fat, total solid and somatic cells[29] ; (b) THz spectra of glucose solutions with different concentrations and scatter plot between actual and predicted glucose concentrations[30]
    (a) Complex dielectric constant of sucrose aqueous solutions with different concentrations [31]; (b) Polarizability of bulk water and hydrated water [31]; (c) THz spectra of nifedipine crystals and mixtures at different concentrations [32]; (d) THz-ATR spectra of nifedipine crystals and nifedipine suspensions with different concentrations [32]
    Fig. 3. (a) Complex dielectric constant of sucrose aqueous solutions with different concentrations [31]; (b) Polarizability of bulk water and hydrated water [31]; (c) THz spectra of nifedipine crystals and mixtures at different concentrations [32]; (d) THz-ATR spectra of nifedipine crystals and nifedipine suspensions with different concentrations [32]
    (a) Real and imaginary parts of dielectric coefficients of distilled water, HeLa, DLD-1 and HEK293[33];(b) Average absorption spectra of ASF and FET [34]
    Fig. 4. (a) Real and imaginary parts of dielectric coefficients of distilled water, HeLa, DLD-1 and HEK293[33];(b) Average absorption spectra of ASF and FET [34]
    (a) The ATR amplitude |RP| and phase arg (Rp) of human skin at different times (0, 45, 90 min) after ingesting the glucosesolution [35]; (b) Relationship between THz- ATR spectral reflectance and theophylline concentration at 0.164 THz[36]; (c) THz timedomainwaveform, frequency spectra, dielectric constant and dielectric loss of LCIS culture solution, MCF10A cells and referenceATR prism without samples[37]; (d) The dielectric constant and dielectric loss of MCF10A living cells exposed andunexposed to 10 mmol/L H2O2 after 0, 1, 2 h were compared [37]
    Fig. 5. (a) The ATR amplitude |RP| and phase arg (Rp) of human skin at different times (0, 45, 90 min) after ingesting the glucosesolution [35]; (b) Relationship between THz- ATR spectral reflectance and theophylline concentration at 0.164 THz[36]; (c) THz timedomainwaveform, frequency spectra, dielectric constant and dielectric loss of LCIS culture solution, MCF10A cells and referenceATR prism without samples[37]; (d) The dielectric constant and dielectric loss of MCF10A living cells exposed andunexposed to 10 mmol/L H2O2 after 0, 1, 2 h were compared [37]
    (a) Refractive index and absorption coefficient and complex permittivity of artificial normal skin and melanoma samples [38] ;(b) THz absorption spectra of two short-chain oligonucleotides and two long-chain oligonucleotides withconcentrations of 5.0 g/ L and 0.5 g/L[39]
    Fig. 6. (a) Refractive index and absorption coefficient and complex permittivity of artificial normal skin and melanoma samples [38] ;(b) THz absorption spectra of two short-chain oligonucleotides and two long-chain oligonucleotides withconcentrations of 5.0 g/ L and 0.5 g/L[39]
    (a) Time variation of absorption coefficient at 0.4, 1.0, 1.6 THz [40]; (b) Complex refractive index and extinction coefficient of SVG P12, HMO6 and U87 cells [41]
    Fig. 7. (a) Time variation of absorption coefficient at 0.4, 1.0, 1.6 THz [40]; (b) Complex refractive index and extinction coefficient of SVG P12, HMO6 and U87 cells [41]
    (a) THz absorption spectra of colon cancer cell lines DLD-1 and HT-29 in different concentration solutions [42];(b) THz- ATR spectra of tyrosine (Tyr) enantiomers (L- and D-Tyr) and racemate (DL-Tyr) in aqueous solution [43]
    Fig. 8. (a) THz absorption spectra of colon cancer cell lines DLD-1 and HT-29 in different concentration solutions [42];(b) THz- ATR spectra of tyrosine (Tyr) enantiomers (L- and D-Tyr) and racemate (DL-Tyr) in aqueous solution [43]
    (a) Comparison of the absorption spectra of the glucose pellet, aqueous glucose (0 mg/dL versus 80 mg/dL) and smart hydrogels before and after reaching swelling equilibrium in aqueous glucose (80 mg/dL) [44]; (b) THz absorption coefficient of U87 cells treated with different concentrations of G-Rg3 for 24 hand THz absorption coefficient of U87 cells at a specific frequency [45]
    Fig. 9. (a) Comparison of the absorption spectra of the glucose pellet, aqueous glucose (0 mg/dL versus 80 mg/dL) and smart hydrogels before and after reaching swelling equilibrium in aqueous glucose (80 mg/dL) [44]; (b) THz absorption coefficient of U87 cells treated with different concentrations of G-Rg3 for 24 hand THz absorption coefficient of U87 cells at a specific frequency [45]
    High-power THz-ATR spectra of α-lactose samples with different concentrations[46, 47]. (a) Time-domain spectra; (b) The corresponding frequency-domain spectra; (c) Characteristic absorption spectra; (d) The change rate of absorption peak position with different concentrations of α-lactose solution
    Fig. 10. High-power THz-ATR spectra of α-lactose samples with different concentrations[46, 47]. (a) Time-domain spectra; (b) The corresponding frequency-domain spectra; (c) Characteristic absorption spectra; (d) The change rate of absorption peak position with different concentrations of α-lactose solution
    Haiqing WANG, Wei SHI. Research progress of THz-ATR technology for detecting biomedical samples[J]. Chinese Journal of Quantum Electronics, 2023, 40(3): 319
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