Haiqing WANG, Wei SHI. Research progress of THz-ATR technology for detecting biomedical samples[J]. Chinese Journal of Quantum Electronics, 2023, 40(3): 319

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- Chinese Journal of Quantum Electronics
- Vol. 40, Issue 3, 319 (2023)

Fig. 1. Schematic diagram of evanescent wave generated by ATR prism
![(a) Verification model of milk fat, total solid and somatic cells[29] ; (b) THz spectra of glucose solutions with different concentrations and scatter plot between actual and predicted glucose concentrations[30]](/richHtml/lzdz/2023/40/3/319/img_02.jpg)
Fig. 2. (a) Verification model of milk fat, total solid and somatic cells[29] ; (b) THz spectra of glucose solutions with different concentrations and scatter plot between actual and predicted glucose concentrations[30]
![(a) Complex dielectric constant of sucrose aqueous solutions with different concentrations [31]; (b) Polarizability of bulk water and hydrated water [31]; (c) THz spectra of nifedipine crystals and mixtures at different concentrations [32]; (d) THz-ATR spectra of nifedipine crystals and nifedipine suspensions with different concentrations [32]](/Images/icon/loading.gif)
Fig. 3. (a) Complex dielectric constant of sucrose aqueous solutions with different concentrations [31]; (b) Polarizability of bulk water and hydrated water [31]; (c) THz spectra of nifedipine crystals and mixtures at different concentrations [32]; (d) THz-ATR spectra of nifedipine crystals and nifedipine suspensions with different concentrations [32]
![(a) Real and imaginary parts of dielectric coefficients of distilled water, HeLa, DLD-1 and HEK293[33];(b) Average absorption spectra of ASF and FET [34]](/Images/icon/loading.gif)
Fig. 4. (a) Real and imaginary parts of dielectric coefficients of distilled water, HeLa, DLD-1 and HEK293[33];(b) Average absorption spectra of ASF and FET [34]
![(a) The ATR amplitude |RP| and phase arg (Rp) of human skin at different times (0, 45, 90 min) after ingesting the glucosesolution [35]; (b) Relationship between THz- ATR spectral reflectance and theophylline concentration at 0.164 THz[36]; (c) THz timedomainwaveform, frequency spectra, dielectric constant and dielectric loss of LCIS culture solution, MCF10A cells and referenceATR prism without samples[37]; (d) The dielectric constant and dielectric loss of MCF10A living cells exposed andunexposed to 10 mmol/L H2O2 after 0, 1, 2 h were compared [37]](/Images/icon/loading.gif)
Fig. 5. (a) The ATR amplitude |RP| and phase arg (Rp) of human skin at different times (0, 45, 90 min) after ingesting the glucosesolution [35]; (b) Relationship between THz- ATR spectral reflectance and theophylline concentration at 0.164 THz[36]; (c) THz timedomainwaveform, frequency spectra, dielectric constant and dielectric loss of LCIS culture solution, MCF10A cells and referenceATR prism without samples[37]; (d) The dielectric constant and dielectric loss of MCF10A living cells exposed andunexposed to 10 mmol/L H2O2 after 0, 1, 2 h were compared [37]
![(a) Refractive index and absorption coefficient and complex permittivity of artificial normal skin and melanoma samples [38] ;(b) THz absorption spectra of two short-chain oligonucleotides and two long-chain oligonucleotides withconcentrations of 5.0 g/ L and 0.5 g/L[39]](/Images/icon/loading.gif)
Fig. 6. (a) Refractive index and absorption coefficient and complex permittivity of artificial normal skin and melanoma samples [38] ;(b) THz absorption spectra of two short-chain oligonucleotides and two long-chain oligonucleotides withconcentrations of 5.0 g/ L and 0.5 g/L[39]
![(a) Time variation of absorption coefficient at 0.4, 1.0, 1.6 THz [40]; (b) Complex refractive index and extinction coefficient of SVG P12, HMO6 and U87 cells [41]](/Images/icon/loading.gif)
Fig. 7. (a) Time variation of absorption coefficient at 0.4, 1.0, 1.6 THz [40]; (b) Complex refractive index and extinction coefficient of SVG P12, HMO6 and U87 cells [41]
![(a) THz absorption spectra of colon cancer cell lines DLD-1 and HT-29 in different concentration solutions [42];(b) THz- ATR spectra of tyrosine (Tyr) enantiomers (L- and D-Tyr) and racemate (DL-Tyr) in aqueous solution [43]](/Images/icon/loading.gif)
Fig. 8. (a) THz absorption spectra of colon cancer cell lines DLD-1 and HT-29 in different concentration solutions [42];(b) THz- ATR spectra of tyrosine (Tyr) enantiomers (L- and D-Tyr) and racemate (DL-Tyr) in aqueous solution [43]
![(a) Comparison of the absorption spectra of the glucose pellet, aqueous glucose (0 mg/dL versus 80 mg/dL) and smart hydrogels before and after reaching swelling equilibrium in aqueous glucose (80 mg/dL) [44]; (b) THz absorption coefficient of U87 cells treated with different concentrations of G-Rg3 for 24 hand THz absorption coefficient of U87 cells at a specific frequency [45]](/Images/icon/loading.gif)
Fig. 9. (a) Comparison of the absorption spectra of the glucose pellet, aqueous glucose (0 mg/dL versus 80 mg/dL) and smart hydrogels before and after reaching swelling equilibrium in aqueous glucose (80 mg/dL) [44]; (b) THz absorption coefficient of U87 cells treated with different concentrations of G-Rg3 for 24 hand THz absorption coefficient of U87 cells at a specific frequency [45]
![High-power THz-ATR spectra of α-lactose samples with different concentrations[46, 47]. (a) Time-domain spectra; (b) The corresponding frequency-domain spectra; (c) Characteristic absorption spectra; (d) The change rate of absorption peak position with different concentrations of α-lactose solution](/Images/icon/loading.gif)
Fig. 10. High-power THz-ATR spectra of α-lactose samples with different concentrations[46, 47]. (a) Time-domain spectra; (b) The corresponding frequency-domain spectra; (c) Characteristic absorption spectra; (d) The change rate of absorption peak position with different concentrations of α-lactose solution

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