Laser microfabrication has the characteristics of ultra fast, ultra precision, etc. It has unique advantages in the field of medical equipment by contrast with traditional processing technology. Especially, it plays an irreplaceable role in the surface processing of biological materials to improve the biocompatibility of materials. The latest application of laser microfabrication in the field of medical equipment manufacturing and processing in recent years is reviewed. The structure and surface manufacturing of vascular stents and bone stents, and the surface modification of biomaterials and antibacterial treatment are emphatically introduced. Finally, the limitations of the current laser micromachining technology are discussed, and the application and development of laser micromachining technology in medical equipment in the future are prospected.