Yankun Qi, Zhihao Zhang, Lü Shichao, Shifeng Zhou. Multifunctional Optical Fibers for Optogenetics[J]. Laser & Optoelectronics Progress, 2023, 60(13): 1316015

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- Laser & Optoelectronics Progress
- Vol. 60, Issue 13, 1316015 (2023)
![Schematic diagram of neural probe using laser as light source, optical fiber as optical signal transmission channel, and metal electrode wire as electrical signal channel[18]](/richHtml/lop/2023/60/13/1316015/img_01.jpg)
Fig. 1. Schematic diagram of neural probe using laser as light source, optical fiber as optical signal transmission channel, and metal electrode wire as electrical signal channel[18]
![Schematic illustration of the fabrication of integrated probe. (a) Design of prefabricated bars for composite materials[34]; (b) schematic diagram of hot stretching process principle[35]; (c) preparation of a typical hydrogel probes[34]; (d) schematic diagram of femtosecond laser micromachining process[36]](/richHtml/lop/2023/60/13/1316015/img_02.jpg)
Fig. 2. Schematic illustration of the fabrication of integrated probe. (a) Design of prefabricated bars for composite materials[34]; (b) schematic diagram of hot stretching process principle[35]; (c) preparation of a typical hydrogel probes[34]; (d) schematic diagram of femtosecond laser micromachining process[36]
![Schematic diagram of the multifunctional probe prefabrication and the application of a living mouse. (a) Schematic diagram of fabrication of optical fiber probe precast; (b) electrophysiological signals at 2 days, 1 week, 1 month, and 2 months after the probe was implanted in the mPFC of mice and subjected to synchronous photogenetic stimulation[27]](/Images/icon/loading.gif)
Fig. 3. Schematic diagram of the multifunctional probe prefabrication and the application of a living mouse. (a) Schematic diagram of fabrication of optical fiber probe precast; (b) electrophysiological signals at 2 days, 1 week, 1 month, and 2 months after the probe was implanted in the mPFC of mice and subjected to synchronous photogenetic stimulation[27]
![Schematic diagram of the preparation of an all-polymer neural probe and its good biocompatibility.(a) Fabrication and thermal stretching of prefabricated rods including recording electrodes, optical waveguides, and microfluidic channels; (b) confocal microscope images of glial scar formation and blood-brain barrier breach around the implanted probe and stainless steel microwires at 1 month respectively (scale bar is100 μm)[37]](/Images/icon/loading.gif)
Fig. 4. Schematic diagram of the preparation of an all-polymer neural probe and its good biocompatibility.(a) Fabrication and thermal stretching of prefabricated rods including recording electrodes, optical waveguides, and microfluidic channels; (b) confocal microscope images of glial scar formation and blood-brain barrier breach around the implanted probe and stainless steel microwires at 1 month respectively (scale bar is100 μm)[37]
![The adaptive bending stiffness of hydrogel hybrid probes and its high matching with mechanical properties of nerve tissue. (a) Description of the concept of adaptive bending stiffness; (b) Mises stress distribution of stainless steel, silica, PC fibers, and hydrogel hybrid probes in brain tissue during lateral micromotion[34]](/Images/icon/loading.gif)
Fig. 5. The adaptive bending stiffness of hydrogel hybrid probes and its high matching with mechanical properties of nerve tissue. (a) Description of the concept of adaptive bending stiffness; (b) Mises stress distribution of stainless steel, silica, PC fibers, and hydrogel hybrid probes in brain tissue during lateral micromotion[34]
![Schematic diagram of the design of LOEF and the demonstration of its light leakage. (a) Three functions of LOEF; (b) schematic diagram of the principle of light leakage by laser ablation of the micro-window; (c) different light leak intensity from a pattern of a single, 1×10, and 2×10 micro-windows (from right to left); (d) image of fluorescent nanobeads in gelatin surrounding the LOEF showing the spatial distribution of light leak[30]](/Images/icon/loading.gif)
Fig. 6. Schematic diagram of the design of LOEF and the demonstration of its light leakage. (a) Three functions of LOEF; (b) schematic diagram of the principle of light leakage by laser ablation of the micro-window; (c) different light leak intensity from a pattern of a single, 1×10, and 2×10 micro-windows (from right to left); (d) image of fluorescent nanobeads in gelatin surrounding the LOEF showing the spatial distribution of light leak[30]
![Schematic diagram of the multifunctional neural probe to simplify optogenetic experiments. (a) Schematic comparison of two-step operation performed by photogenetic experiment and one-step operation performed by multifunctional fiber probe; (b) schematic illustration of simultaneous viral delivery, optical stimulation and electrical recording in mPFC of mice with fiber probe; (c) integration of fiber probe photoelectric function with microfluidic channels[34,37]](/Images/icon/loading.gif)
Fig. 7. Schematic diagram of the multifunctional neural probe to simplify optogenetic experiments. (a) Schematic comparison of two-step operation performed by photogenetic experiment and one-step operation performed by multifunctional fiber probe; (b) schematic illustration of simultaneous viral delivery, optical stimulation and electrical recording in mPFC of mice with fiber probe; (c) integration of fiber probe photoelectric function with microfluidic channels[34,37]

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