The micro-vibration signal existing as noise is one of the main facts that cause the interference and affect the machining accuracy. The premise of interference elimination is the precise measurement and location of microvibration source. A micro-vibration location system based on full-fiber micro-vibration sensor is provided, aiming at the shortcoming of existing location system based on fiber. At least 4 micro-vibration sensors are needed in this system, and the position of micro-vibration source is calculated by measuring the time difference of arrival (TDOA) of vibration signal at one sensor relative to other 3 sensors. The performance of sensors and location system is verified by experiment, the relative location error is inferior to 0.56%, and it is stable and reliable.