The technique of computer-generated holography (CGH) is introduced into the experimental system on laser ultrasonic non-destructive evaluation (NDE). This system employs a direct-search algorithm to generate the hologram and further reconstructs the hologram via aliquid crystal spatial light modulator. Specifically, a generation and reconstruction method is applied to help the spatial modulation of the laser pulse to excite narrow-band ultrasound. Due to the robusticity of the algorithm and the flexibility of the reconstruction method, this method can simplify the laser ultrasonic setup and substantially shorten the experiment period. Thus there will be a variety of applications for this system in the fields of NDE.