The systematic restoration of industrial and mining land for resource-based cities is a critical method to achieve sustainable development. It is necessary to integrate ecological restoration of industrial and mining land in the construction of regional ecological security pattern as whole. Based on the ecological security pattern and circuit theory, this study identified the key points and ecological corridors in 2000, 2005, 2011 and 2017 in Wuhai, Inner Mongolia Autonomous Region, a typical resourced-based city, and established the important level of restoration priority. The results show that: (1) From 2000 to 2017, the increase of industrial and mining land area and urban expansion on corridor paths led to a decline in the quality and changes in the location of the ecological corridors. The total length of the seven minimum cost paths increased from 120.74 km to 125.71 km; the total of cost weighted distance increased from 692.58 km to 1162.28 km. (2) 14 barriers are identified in 2017 with a total area of 16.06 km2, including 12 key points with a total area of 14.09 km2. (3) The restoration area is the identified ecological corridors from 2000 to 2017 and the key points in 2017, which were divided into important level of restoration priority, with a total area of 475.86 km2. Based on the paradigm of regional ecological security pattern, the study coordinates the ecological restoration of industrial and mining land, making it an organic whole for the restoration of territorial space, and providing decision-making reference for the sustainable development of resource-based cities.