Fluorescence lifetime T and absorption spectra of Khodamine 6G (R6G) at different concentrations have been measured in a variety of solvents, such as methanol, ethanol n-propyl-, n-butyl and t-amyl alcohols, acetonitrile and water etc. The variation of τ for E6G in these solutions (except H2O) at 10-4 md. is related linearily to the ability of solvent to form hydrogen-bonding. This finding in combination with the absorption measurement leads us to a suggestion that the influence of solute-solvent interaction via hydrogen-bonding on aggregation between R6G molecules is responsible for observed solvent effect on fluorescence lifetime.