• Chinese Journal of Lasers
  • Vol. 45, Issue 2, 207018 (2018)
Li Conghui1、2, Cao Ruofan1、2、*, Xu Xiayu1、2, Li Fei2、3, Zhang Zhenxi1, and Xu Feng1、2
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
  • 3[in Chinese]
  • show less
    DOI: 10.3788/CJL201845.0207018 Cite this Article Set citation alerts
    Li Conghui, Cao Ruofan, Xu Xiayu, Li Fei, Zhang Zhenxi, Xu Feng. Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing[J]. Chinese Journal of Lasers, 2018, 45(2): 207018 Copy Citation Text show less
    Schematic of lensless imaging technology[27-29]. (a) Shadow lensless microscopic imaging; (b) fluorescence lenslessmicroscopic imaging; (c) transmission digital holography lensless microscopic imaging; (d) reflective digital holography lensless microscopic imaging
    Fig. 1. Schematic of lensless imaging technology[27-29]. (a) Shadow lensless microscopic imaging; (b) fluorescence lenslessmicroscopic imaging; (c) transmission digital holography lensless microscopic imaging; (d) reflective digital holography lensless microscopic imaging
    Principle of super-resolution algorithm
    Fig. 2. Principle of super-resolution algorithm
    3D structures of acini analyzed by lensless digital holography microscopic imaging technology. (a) Schematic of the device for the detection of acinar morphology; (b) normal acini; (c) acini lack of polarity
    Fig. 3. 3D structures of acini analyzed by lensless digital holography microscopic imaging technology. (a) Schematic of the device for the detection of acinar morphology; (b) normal acini; (c) acini lack of polarity
    Application of lensless imaging technology for (a) cardiotoxicity detection; (b) sperm shape analysis[57]
    Fig. 4. Application of lensless imaging technology for (a) cardiotoxicity detection; (b) sperm shape analysis[57]
    Application of lensless imaging technology for bacteria detection. (a) Bacteria detection device of lensless digital coaxial holography microscopy based on wetting thin film[59]; (b) whole cell biosensor biochip based on biological luminescence[63]
    Fig. 5. Application of lensless imaging technology for bacteria detection. (a) Bacteria detection device of lensless digital coaxial holography microscopy based on wetting thin film[59]; (b) whole cell biosensor biochip based on biological luminescence[63]
    SystemLight sourceStructure requirementReconstructionRange of field
    Shadow imagingMonochrome orwhite light LEDSample must beclose to CCDSuper-resolution[47-50]Semitransparent oropaque samples
    Fluorescence imagingMonochromeLED or laserFiltersSuper-resolution[47-50],compressive sampling[33]Fluorescent samples
    Holographic imagingLaserPinholePhase retrieval[40-41],twin image elimination[42],angular spectrum[43]Transparent orsemitransparent samples
    Table 1. Comparison of three types of lensless imaging technology
    Li Conghui, Cao Ruofan, Xu Xiayu, Li Fei, Zhang Zhenxi, Xu Feng. Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing[J]. Chinese Journal of Lasers, 2018, 45(2): 207018
    Download Citation