The fluorescence quantum yield of new photosensitizer-aluminum sulfonated phthalosyanine (AISPC) was measured as 0.53, 21 times higher than that of HPD. which shows that AISPC has potential usage in tumor detection. In vivo measurement on mouse by using He-Ne laser induced fluorescence showed that, AISFC can selectively retain in 8-180 tare cm a, and the maximum tumor; normal tissue ratio achieved 24-36 h after AISPC injection is about 2.5:1.