In the present work, the authors investigated interaction of cucurbit［n=7, 8］urils(Q<参考文献原文>, Q<参考文献原文>) with 2-methylindol(Me) and 3-methylindol(Sk), influences of pH and temperature on the interaction of Q<参考文献原文>, Q<参考文献原文> with the guests and calculations of the stability constants and thermodynamic parameters by using fluorescence spctroscopy. The results show that: the interation ratios are 1∶1 of host: guest for all systems, except the Q<参考文献原文>-Sk system, for which the ratio is 1∶2 of host: guest; the interaction ratios of the host: guest systems did not change in the range of pH 1~11 and temperature between 298 and 313 K; the stability constant is the largest at pH 1 and room temperature. The thermodynamic parameter revealed that the interaction of the host and the guest of spontaneitied.