The corresponding Copper Phthalocyanine(CuPc)nanoparticles have been fabricated in aqueous solution by laser ablation with the α and β crystalline forms of CuPc original powders respectively.X ray diffraction patterns,UV Vis absorption spectroscopy and Fourier transform infrared spectroscopy have been used to analyze the crystalline structures of obtained CuPc nanoparticles.The results have shown that the crystalline structures of the α and β forms of CuPc have no change before and after laser ablation.It indicates that both α and β forms of CuPc are stable during laser ablation and laser ablation is a simple and efficiency method to fabricate the nanoparticles of above two forms of CuPc.