Due to the limitation of measurement methods, the existing radiation calibration system can only realize radiation measurement when the transmittance of the optical system of small-medium infrared imaging simulator changes, but not when the field-of-view aperture of large infrared imaging simulator changes. Aiming at the problem that part of the simulation state of the large-scale infrared imaging simulator cannot be evaluated, a measurement method based on imaging/light intensity change response is proposed, and a new infrared radiation calibration system is designed. After the development of the system is completed, a multi-parameter calibration method is proposed to meet the requirements of multi-radiation parameter measurement for infrared imaging simulator. The irradiance of the system is 6×10 ^-10-7×10 ^-4 W/cm ², the working band is 2.05--2.55 μm and 3.70--4.80 μm, and the measurement uncertainty is 1.88%. Finally, the new system is used to calibrate the output radiation of a large-scale infrared imaging simulator under different simulation states. The calibration results show that the new method and new system can make the large-scale infrared imaging simulator realize multi-parameter measurement in full simulation state.