An adaptive optical system with a liquid crystal spatial modulator device as the wave-front aberration corrector for the human retina imaging was constructed A Shack-Hartmann wave-front sensor was used to test the wave-front aberration of the eye A near-infrared (NIR) laser (808 nm) was used as the beacon light source for measuring the wave-front and the light source for the retina imaging A model eye was constructed to analyse the impact of the laser speckle on retina imaging on camera and wave-front measurement The method of rotating diffuser was confirmed feasible and valid for reducing the speckle And then, the contrast experiment that illuminates the vivo human eye by the laser with the diffuser rotating or not was carried out and the retina images with and without speckle were taken Finally a series of images of the retina cells were obtained after the aberration of the eye was corrected After correction the residual errors of the system aberration were less than 0 1 λ It is testified that the laser speckle can be reduced by rotating diffuser, and the NIR laser after speckle reduction can be used as the beacon light source and the illuminating light for the retina imaging As a result, the human eye aberration can be corrected continuously and a video of the retina can be taken.