REDOX IMAGING OF THE p53-DEPENDENT MITOCHONDRIAL REDOX STATE IN COLON CANCER EX VIVO

HE N. XU; MIN FENG; LILY MOON; NATHAN DOLLOFF; WAFIK EL-DEIRY; LIN Z. LI

doi:10.1142/s1793545813500168

[1] A. M. Puzio-Kuter, "The role of p53 in metabolic regulation," Genes Cancer 2, 385-391 (2011).

[2] E. Gottlieb, K. H. Vousden, "p53 Regulation of metabolic pathways," Cold Spring Harb. Perspect. Biol. 2, a001040 (2010).

[3] S. Matoba, J. G. Kang, W. D. Patino, A. Wragg, M. Boehm, O. Gavrilova, P. J. Hurley, F. Bunz, P. M. Hwang, "p53 Regulates mitochondrial respiration," Science 312, 1650-1653 (2006).

[4] J. Fields, J. J. Hanisch, J. W. Choi, P. M. Hwang, "How does p53 regulate mitochondrial respiration " IUBMB Life 59, 682-684 (2007).

[5] L. Z. Li, R. Zhou, T. Zhong, L. Moon, E. J. Kim, H. Qiao, S. Pickup, M. J. Hendrix, D. Leeper, B. Chance, J. D. Glickson, "Predicting melanoma metastatic potential by optical and magnetic resonance imaging," Adv. Exp. Med. Biol. 599, 67-78 (2007).

[6] H. N. Xu, S. Nioka, J. D. Glickson, B. Chance, L. Z. Li, "Quantitative mitochondrial redox imaging of breast cancer metastatic potential," J. Biomed. Opt. 15, 036010 (2010).

[7] L. Z. Li, R. Zhou, H. N. Xu, L. Moon, T. Zhong, E. J. Kim, H. Qiao, R. Reddy, D. Leeper, B. Chance, J. D. Glickson, "Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential," Proc. Natl. Acad. Sci. USA 106, 6608-6613 (2009).

[8] H. N. Xu, S. Nioka, B. Chance, L. Z. Li, "Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model," Biomarker Res. 1, 6 (2013).

[9] R. A. Cairns, I. S. Harris, T. W. Mak, "Regulation of cancer cell metabolism," Nat. Rev. Cancer 11, 85 (2011).

[10] H. N. Xu, B. Wu, S. Nioka, B. Chance, L. Z. Li, "Quantitative redox scanning of tissue samples using a calibration procedure," J. Innov. Opt. Health Sci. 2, 375-385 (2009).

[11] B. Chance, B. Schoener, R. Oshino, F. Itshak, Y. Nakase, "Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals," J. Biol. Chem. 254, 4764-4771 (1979).

[12] B. Quistorff, J. C. Haselgrove, B. Chance, "High spatial resolution readout of 3-D metabolic organ structure: An automated, low-temperature redox ratio-scanning instrument," Anal. Biochem. 148, 389-400 (1985).

[13] K. Ozawa, B. Chance, A. Tanaka, S. Iwata, T. Kitai, I. Ikai, "Linear correlation between acetoacetate beta-hydroxybutyrate in arterial blood and oxidized flavoprotein reduced pyridine-nucleotide in freeze-trapped human liver-tissue," Biochim. Biophys. Acta 1138, 350-352 (1992).

[14] D. L. Dexter, E. N. Spremulli, Z. Fligiel, J. A. Barbosa, R. Vogel, A. VanVoorhees, P. Calabresi, "Heterogeneity of cancer cells from a single human colon carcinoma," Am. J. Med. 71, 949 (1981).

[15] M. G. Brattain, M. E. Marks, J. McCombs, W. Finely, D. E. Brattain, "Characterization of human colon carcinoma cell lines isolated from a single primary tumour," Br. J. Cancer 47, 373-381 (1983).

[16] M. G. Brattain, A. E. Levine, S. Chakrabarty, L. C. Yeoman, J. K. V. Willson, B. Long, "Heterogeneity of human colon carcinoma," Cancer Metastasis Rev. 3, 177 (1984).

[17] A. Rajput, I. Dominguez San Martin, R. Rose, A. Beko, C. LeVea, E. Sharratt, R. Mazurchuk, R. M. Hoffman, M. G. Brattain, J. Wang, "Characterization of HCT116 human colon cancer cells in an orthotopic model," J. Surg. Res. 147, 276-281 (2008).

[18] S. Wang, A. Mintz, K. Mochizuki, J. F. Dorsey, J. M. Ackermann, A. Alavi, W. S. El-Deiry, "Multimodality optical imaging and 18F-FDG uptake in wild-type p53-containing and p53-null human colon tumor xenografts," Cancer Biol. Ther. 6, 1649-1653 (2007).

[19] H. N. Xu, S. Nioka, L. Z. Li, "Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model," Biomarker Res. 1, 6 (2013).

[20] H. N. Xu, G. Zheng, J. Tchou, S. Nioka, L. Z. Li, "Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging," SpringerPlus 2, 73 (2013).

[21] K. Bensaad, A. Tsuruta, M. A. Selak, M. N. C. Vidal, K. Nakano, R. Bartrons, E. Gottlieb, K. H. Vousden, "TIGAR, a p53-inducible regulator of glycolysis and apoptosis," Cell 126, 107-120 (2006).

[22] L. Z. Li, "Imaging mitochondrial redox potential and its possible link to tumor metastatic potential," J. Bioenerg. Biomembr. 44, 645-653 (2012).

[23] H. N. Xu, R. Zhou, S. Nioka, B. Chance, J. D. Glickson, L. Z. Li, "Histological basis of MR/optical imaging of human melanoma mouse xenografts spanning a range of metastatic potentials," Adv. Exp. Med. Biol. 645, 247-253 (2009).

[24] Y. Gu, Z. Qian, J. Chen, D. Blessington, N. Ramanujam, B. Chance, "High-resolution threedimensional scanning optical image system for intrinsic and extrinsic contrast agents in tissue," Rev. Sci. Instrum. 73, 172-178 (2002).