In the present paper,Fourier transform infrared (FTIR) spectroscopy was used to study the chemical characterizations of cornu saigae tataricae,cornu antelopis block and the mixed sample of them. The results show that there are significant differences between FTIR characterizations of cornu saigae tataricae and cornu antelopes block. The infrared spectra of cornu saigae tataricae are mainly composed of the absorption bands of protein,but in cornu antelopis block the absorption bands of Ca3(PO4)2 are observed beside protein. And other obvious differences were detected in the FTIR spectra of the two samples,amide bands,C—O stretching vibration bands, and CH stretching vibration bands. The drug of cornu saigae tataricae,cornu antelopis block,and the mixed sample of them could be identified rapidly according to the differences. This experiment gave the scientific data for the researches on chemical components and quality evaluation system of cornu saigae tataricae,and provides the identification method of cornu saigae tataricae and cornu antelopis block.