The sensing characteristics of irradiated fiber Bragg gratings (FBGs) and Fabry-Perot interferometers (FPIs) were investigated under a 2 MGy dose of gamma radiation. The study found that the pressure sensitivity of FP sensors after irradiation was stable, while the temperature sensitivity of FBG sensors was unstable, and both wavelengths displayed a shift. These findings offer the possibility for the application of FP pressure sensors in the gamma radiation environments, and FBG sensors require further research to be suitable for application in the nuclear radiation environments.