Deep-learning powered whispering gallery mode sensor based on multiplexed imaging at fixed frequency

Anton V. Saetchnikov; Elina A. Tcherniavskaia; Vladimir A. Saetchnikov; Andreas Ostendorf

doi:10.29026/oea.2020.200048

[1] F Vollmer, S Arnold. Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nat Methods, 5, 591-596(2008).

[2] M R Foreman, J D Swaim, F Vollmer. Whispering gallery mode sensors. Adv Opt Photonics, 7, 168-240(2015).

[3] Y N Zhang, T M Zhou, B Han, A Z Zhang, Y Zhao. Optical bio-chemical sensors based on whispering gallery mode resonators. Nanoscale, 10, 13832-13856(2018).

[4] X F Jiang, A J Qavi, S H Huang, L Yang. Whispering-gallery sensors. Matter, 3, 371-392(2020).

[5] V B Braginsky, M L Gorodetsky, V S Ilchenko. Quality-factor and nonlinear properties of optical whispering-gallery modes. Phys Lett A, 137, 393-397(1989).

[6] K J Vahala. Optical microcavities. Nature, 424, 839-846(2003).

[7] F Vollmer, D Braun, A Libchaber, M Khoshsima, I Teraoka et al. Protein detection by optical shift of a resonant microcavity. Appl Phys Lett, 80, 4057(2002).

[8] D K Armani, T J Kippenberg, S M Spillane, K J Vahala. Ultra-high-q toroid microcavity on a chip. Nature, 421, 925-928(2003).

[9] T J Kippenberg, S M Spillane, D K Armani, K J Vahala. Fabrication and coupling to planar high-Q silica disk microcavities. Appl Phys Lett, 83, 797-799(2003).

[10] I M White, H Oveys, X D Fan. Liquid-core optical ring-resonator sensors. Opt Lett, 31, 1319-1321(2006).

[11] F Vollmer, L Yang. Review label-free detection with high-q microcavities: a review of biosensing mechanisms for integrated devices. Nanophotonics, 1, 267-291(2012).

[12] Y Y Zhi, X C Yu, Q H Gong, L Yang, Y F Xiao. Single nanoparticle detection using optical microcavities. Adv Mate, 29, 1604920(2017).

[13] V R Dantham, S Holler, C Barbre, D Keng, V Kolchenko et al. Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity. Nano Lett, 13, 3347-3351(2013).

[14] M D Baaske, F Vollmer. Optical observation of single atomic ions interacting with plasmonic nanorods in aqueous solution. Nat Photonics, 10, 733-739(2016).

[15] L N He, Ş K Özdemir, J G Zhu, W Kim, L Yang. Detecting single viruses and nanoparticles using whispering gallery microlasers. Nat Nanotechnol, 6, 428-432(2011).

[16] U Bog, T Laue, T Grossmann, T Beck, T Wienhold et al. On-chip microlasers for biomolecular detection via highly localized deposition of a multifunctional phospholipid ink. Lab Chip, 13, 2701-2707(2013).

[17] W J Chen, Ş K Özdemir, G M Zhao, J Wiersig, L Yang. Exceptional points enhance sensing in an optical microcavity. Nature, 548, 192-196(2017).

[18] X Zhou, L Zhang, W Pang. Performance and noise analysis of optical microresonator-based biochemical sensors using intensity detection. Opt Express, 24, 18197-18208(2016).

[19] T Reynolds, N Riesen, A Meldrum, X D Fan, J M M Hall et al. Fluorescent and lasing whispering gallery mode microresonators for sensing applications. Laser Photonics Rev, 11, 1600265(2017).

[20] J D Swaim, J Knittel, W P Bowen. Detection of nanoparticles with a frequency locked whispering gallery mode microresonator. Appl Phys Lett, 102, 183106(2013).

[21] S Rosenblum, Y Lovsky, L Arazi, F Vollmer, B Dayan. Cavity ring-up spectroscopy for ultrafast sensing with optical microresonators. Nat Commun, 6, 6788(2015).

[22] G C Righini, S Soria. Biosensing by wgm microspherical resonators. Sensors, 16, 905(2016).

[23] J Su. Label-free biological and chemical sensing using whispering gallery mode optical resonators: past, present, and future. Sensors, 17, 540(2017).

[24] L Cai, J Y Pan, Y Zhao, J Wang, S Xiao. Whispering gallery mode optical microresonators: structures and sensing applications. Phys Status Solidi A, 217, 1900825(2020).

[25] G Schweiger, R Nett, T Weigel. Microresonator array for high-resolution spectroscopy. Opt Lett, 32, 2644-2646(2007).

[26] V A Saetchnikov, E A Tcherniavskaia. Using optical resonance of whispering gallery modes in microspheres for real-time detection and identification of biological compounds. J Appl Spectrosc, 77, 714-721(2010).

[27] H A Huckabay, S M Wildgen, R C Dunn. Label-free detection of ovarian cancer biomarkers using whispering gallery mode imaging. Biosens Bioelectron, 45, 223-229(2013).

[28] A B Petermann, A Varkentin, B Roth, U Morgner, M Meinhardt-Wollweber. All-polymer whispering gallery mode sensor system. Opt Express, 24, 6052-6062(2016).

[29] A V Saetchnikov, E A Tcherniavskaia, V V Skakun, V A Saetchnikov, A Ostendorf. Reusable dispersed resonators-based biochemical sensor for parallel probing. IEEE Sens J, 19, 7644-7651(2019).

[30] Proceedings Volume 11354, Optical Sensing and Detection VI 1135427 (SPIE, 2020); https://doi.org/10.1117/12.2555391.

[31] E A Tcherniavskaia, V A Saetchnikov. Application of neural networks for classification of biological compounds from the characteristics of whispering-gallery-mode optical resonance. J Appl Spectrosc, 78, 457-460(2011).

[32] D Hu, C L Zou, H L Ren, J Lu, Z C Le et al. Multi-parameter sensing in a multimode self-interference micro-ring resonator by machine learning. Sensors, 20, 709(2020).

[33] V V Kornienko, I A Nechepurenko, P N Tananaev, E D Chubchev, A S Baburin et al. Machine learning for optical gas sensing: a leaky-mode humidity sensor as example. IEEE Sens J, 20, 6954-6963(2020).

[34] Z S Ballard, D Shir, A Bhardwaj, S Bazargan, S Sathianathan et al. Computational sensing using low-cost and mobile plasmonic readers designed by machine learning. ACS nano, 11, 2266-2274(2017).

[35] Proceedings Volume 10678, Optical Micro- and Nanometrology VⅡ 106780W (SPIE, 2018); http://doi.org/10.1117/12.2309660.

[36] Harris D C. Quantitative Chemical Analysis 6th ed (W. H. Freeman, New York, 2003).

[37] H P Loock, P D Wentzell. Detection limits of chemical sensors: applications and misapplications. Sens Actuators B Chem, 173, 157-163(2012).