Detection of low-concentration EGFR with a highly sensitive optofluidic resonator

Jianfeng Shang; Hailang Dai; Yun Zou; Xianfeng Chen

doi:10.3788/COL201715.092301

Journals >Chinese Optics Letters >Volume 15 >Issue 9 >Page 092301 > Article

Chinese Optics Letters
Vol. 15, Issue 9, 092301 (2017)

Detection of low-concentration EGFR with a highly sensitive optofluidic resonator

Jianfeng Shang¹, Hailang Dai¹, Yun Zou², and Xianfeng Chen^1、*

Author Affiliations

¹State Key Laboratory of Advanced Optical Communication Systems and Networks, Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China

²Shanghai Key Laboratory of Crime Science Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200083, China

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DOI: 10.3788/COL201715.092301 Cite this Article Set citation alerts

Jianfeng Shang, Hailang Dai, Yun Zou, Xianfeng Chen. Detection of low-concentration EGFR with a highly sensitive optofluidic resonator[J]. Chinese Optics Letters, 2017, 15(9): 092301 Copy Citation Text

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Abstract

A hollow-core metal-cladding waveguide (HCMW) optofluidic resonator that works based on a free-space coupling technique is designed. An HCMW can excite ultra-high-order modes (UOMs) at the coupled angle, which can be used as an optofluidic resonator to detect alterations of the epidermal growth factor receptor (EGFR) concentration. Theoretical analysis shows that the UOMs excited in the HCMW have a highly sensitive response to the refractive index (RI) variation of the guiding layer. An EGFR solution with a 0.2 ng/mL alteration is detected, and the RI variation caused by the concentration alteration is about

2.5 \times 10^{3}

k_{1} h_{1} = m π + \arctan (\frac{f_{1}}{f_{2}} \frac{p_{2}}{k_{1}}) + \arctan (\frac{f_{1}}{f_{3}} \frac{p_{3}}{k_{1}}), m = 0, 1, 2, \dots,

(1)

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{\begin{matrix} k_{1} = {(k_{0}^{2} n_{1}^{2} - β^{2})}^{1 / 2} \\ p_{2} = {(β^{2} - k_{0}^{2} n_{2}^{2})}^{1 / 2} \\ p_{3} = {(β^{2} - k_{0}^{2} n_{3}^{2})}^{1 / 2} \end{matrix},

(2)

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f_{j} = {\begin{matrix} 1 & For TE mode \\ n_{j}^{2} & For T M mode \end{matrix} (j = 0, 1, 2),

(3)

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n_{eff} = β / k_{0} = n_{0} \sin θ,

(4)

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{\begin{cases} k_{1}^{m - 1} h = (m - 1) π + \arctan (\frac{n_{1}^{2} p_{2}^{m - 1}}{n_{2}^{2} k_{1}^{m - 1}}) + \arctan (\frac{n_{1}^{2} p_{3}^{m - 1}}{n_{3}^{2} k_{1}^{m - 1}}) \\ k_{1}^{m} h = m π + \arctan (\frac{n_{1}^{2} p_{2}^{m}}{n_{2}^{2} k_{1}^{m}}) + \arctan (\frac{n_{1}^{2} p_{3}^{m}}{n_{3}^{2} k_{1}^{m}}) \\ k_{1}^{m + 1} h = (m + 1) π + \arctan (\frac{n_{1}^{2} p_{2}^{m + 1}}{n_{2}^{2} k_{1}^{m + 1}}) + \arctan (\frac{n_{1}^{2} p_{3}^{m + 1}}{n_{3}^{2} k_{1}^{m + 1}}) \end{cases} .

(5)

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Jianfeng Shang, Hailang Dai, Yun Zou, Xianfeng Chen. Detection of low-concentration EGFR with a highly sensitive optofluidic resonator[J]. Chinese Optics Letters, 2017, 15(9): 092301

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