Cylindrical vector beam can be widely used in the fields of photoetching, optical micro processing, optical tweezers and optical superresolution. To overcome the existing problems of the complexity of its setup and the unadjustable polarization, generation of cylindrical vector beam with adjustable polarization based on vortex phase modulation and interference is studied both theoretically and experimentally. Feasibility of our scheme is proved in theory, and intensity distributions of radially polarized beam and azimuthally polarized beam are simulated. Meanwhile, related experiments are conducted to prove the correctness of the theory. By rotating the relative angle between two vortex phase plates, the obtained radially polarized beam can be changed into azimuthally polarized one. Experimental results are agree with the theoretical analyses.