First | Photofrin® (Porfimer sodium) | Esophageal cancer, lung cancer, microinvasive endobronchial cancer, gastric and papillary bladder, cervical dysplasia, and cancer | Clinically approved |
HiPorfin | Esophageal cancer, lung cancer, bladder cancer, oral cancer, and skin cancer |
Hemoporfin | Port wine stain |
Second | Foscan® (Temoporfin) | Approved: head and neck cancer | Clinically approved |
Preclinical testing: breast and pancreatic cancer |
Visudyne® (Verteporfin) | Age-related macular degeneration |
Laserphyrin®/NPe6/Talaporfin (Chlorin m-THPC) | Approved: early lung cancer |
Clinical trials: hepatocellular cancer and liver metastasis |
Levulan® (Protoporphyrin) | Actinic keratosis |
Metvix®/Metvixia® (Protoporphyrin) | Actinic keratosis and basal cell carcinoma |
Photochlor (HPPH) | BCC, lung, head, and neck cancers |
Ameluz®/Levulan®(5-ALA) | Approved: actinic keratosis |
Clinical trials: brain |
5-ALA | Condyloma acuminatum |
Tookad® (Pheophorbides) | Prostate cancer |
Redaporfin® | Biliary tract cancer, head, and neck |
Purlytin® | Metastatic breast, cancer, AIDS-related Kaposi’s sarcoma, and basal cell carcinomas | Under clinical trials |
Lutrin® and Lutex® (metalloporphyrins) | Clinicaltrials: recurrent prostate cancer and cervical cancer |
Preclinical testing: recurrent breast cancer |
Photrex | Age-related macular degeneration |
Antrin | Coronary artery disease |
Fotolon | Nasopharyngeal and sarcoma |
Radachlorin | Skin diseases |
Hypericin | Bladder cancer and nasopharyngeal cancer |
Chalcogenopyrylium dyes | Prostate cancer, breast cancer, and colon cancer |
Phenothiazinium dye-methylene Blue | Bladder cancer, colon cancer, and AIDS-related Kaposi’s sarcoma |
Phenothiazinium dye-Nile blue and derivatives | AIDS-related Kaposi’s sarcoma and T-cell leukemia |
Phenothiazinium dye-toluidine Blue | Bladder cancer and mouse mammary sarcoma |
Cyanines | Leukemia and lymphoma |
ADPM06 | Breast cancer and mouse lung cancer |
Photocynine | Esophageal carcinoma |
DVDMS | Esophageal cancer |
Third | Functional photosensitizer | | Being developed |