• Spectroscopy and Spectral Analysis
  • Vol. 41, Issue 12, 3802 (2021)
Xue-ning FEI*;, Yuan-jie ZHENG, Ying-chun GU, Guang-min LI, Hong-bin ZHAO, and Bao-lian ZHANG
Author Affiliations
  • School of Science, Tianjin Urban Construction University, Tianjin 300384, China
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    DOI: 10.3964/j.issn.1000-0593(2021)12-3802-06 Cite this Article
    Xue-ning FEI, Yuan-jie ZHENG, Ying-chun GU, Guang-min LI, Hong-bin ZHAO, Bao-lian ZHANG. Fluorescence Imaging and Chiral Specific Biological Recognition[J]. Spectroscopy and Spectral Analysis, 2021, 41(12): 3802 Copy Citation Text show less
    Structural differences of folate receptor and pocket relationship of folate binding(a), (b): The figure show the positive and negative sides of folate receptor;(c): The triangle cavity of folate inclusion; (d): The difference of folate α and β subtypes
    Fig. 1. Structural differences of folate receptor and pocket relationship of folate binding
    (a), (b): The figure show the positive and negative sides of folate receptor;(c): The triangle cavity of folate inclusion; (d): The difference of folate α and β subtypes
    Spectrogram of sulfhydryl terminated CdTe nanocrystals
    Fig. 2. Spectrogram of sulfhydryl terminated CdTe nanocrystals
    Circular dichotomous peaks and structures of CdTe quantum dots
    Fig. 3. Circular dichotomous peaks and structures of CdTe quantum dots
    Pyroglutamic acid modified CdSe/ZnS quantum dots
    Fig. 4. Pyroglutamic acid modified CdSe/ZnS quantum dots
    Chiral space of folate receptor subtypes FRα and FRβ and their interaction with chiral quantum dots
    Fig. 5. Chiral space of folate receptor subtypes FRα and FRβ and their interaction with chiral quantum dots
    种类发射波长/nm结构修饰修饰后分子优势
    香豆素类
    (Coumarin)
    <4003、 4位引入吸电子基团, 5~8位引入推电子基团发射波长移至480 nm以上、 量子产率达0.26、 Stokes位移接近100 nm
    花菁类
    (Cyanine dye)
    700~900改变次甲基链的长度荧光波长发生红移、 灵敏度高、 生物相容性好、 化学键合能力强
    氟硼类
    (BODIPY)
    5002、 6位烷基取代修饰大的共轭π键结构芳香环, 增大分子共轭体系发射波长可增至540 nm以上、 量子产率高、 检测灵敏、 吸收峰锐利及荧光带窄及稳定性能高
    罗丹明类
    (Rhodamine B)
    580通过螺环调控氧杂蔥共轭结构与荧光特性检出限低至2 pmol·L-1、 量子产率高、 摩尔消光系数大、 水溶性好
    Table 1. Molecular structure modification of organic dyes probes
    Xue-ning FEI, Yuan-jie ZHENG, Ying-chun GU, Guang-min LI, Hong-bin ZHAO, Bao-lian ZHANG. Fluorescence Imaging and Chiral Specific Biological Recognition[J]. Spectroscopy and Spectral Analysis, 2021, 41(12): 3802
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