Author Affiliations
1Life Sciences and Medicine, School of Biomedical Engineering (Suzhou), University of Science and Technology of China, Suzhou 215163, Jiangsu, China2Medical Optical Research Laboratory, Suzhou Institute of Biomedical Engineering Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China3Jinan Guoke Medical Technology Development Co., Ltd., Jinan 250102, Shandong, China4Shenyang Guoke Medical Technology Development Co., Ltd., Shenyang 110167, Liaoning, Chinashow less
Fig. 1. Structure of human eye auto-focus and pupil center auto-alignment device
Fig. 2. Schematic of optical path of imaging module
Fig. 3. Flowchart of pupil center positioning and alignment algorithm
Fig. 4. Collected image of human eye and ROI image. (a) Original image of human eye; (b) ROI image of pupil
Fig. 5. Grayscale histogram distributions before and after extraction of ROI. (a) Grayscale histogram distribution of original image; (b) grayscale histogram distribution of ROI
Fig. 6. ROI image after threshold segmentation. (a) Image after T1 threshold segmentation; (b) image after T2 threshold segmentation
Fig. 7. Schematic diagrams of pupil center and optical axis center. (a) Pupil identification and center point; (b) optical axis ellipse fitting and center point
Fig. 8. Schematic diagram of relative position of pupil center and optical axis
Fig. 9. Schematic diagrams of defocus sequence-1 of human eyes. (a) 5th image of sequence; (b) 9th image of sequence; (c) 13th image of sequence; (d) 17th image of sequence; (e) 21st image of sequence
Fig. 10. Normalized sharpness evaluation curves of human eye defocused image sequences. (a) Sequence 1; (b) sequence 2;(c) sequence 3; (d) sequence 4
Fig. 11. Partial images of sequence 4 in human eye defocused image. (a) 8th image of sequence; (b) 9th image of sequence
Fig. 12. Error between pupil center coordinates obtained by three algorithms and manually calibrated pupil center coordinates
Fig. 13. Processing results of algorithm in this paper under complex conditions. (a) Dark light condition; (b) bright light condition; (c)(d) partial occlusion of pupil
Evaluation function | TPF /ms | R | Fsen | Unimodality | Accuracy |
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FMTG | 13.0 | 93.531 | 0.329 | √ | √ | Brenner | 14.1 | 2.800 | 0.188 | — | — | Tenengrad | 42.8 | 1.561 | 0.114 | √ | √ | SMD | 16.1 | 1.138 | 0.058 | × | × | Laplace | 13.8 | 1.110 | 0.026 | × | × | Vollaths | 15.7 | 1.204 | 0.050 | × | × | Variance | 15.5 | 1.278 | 0.053 | × | × |
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Table 1. Average performance indexes of evaluation curves of out-of-focus sequences 1-4 of human eye images
Method | Average time /ms | Accuracy /% | Average error /pixel |
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LPC | 10.2 | 97.14 | 1.4 | Improved Hough | 584.7 | 53.33 | 3.3 | Hough | 5100.4 | 14.29 | 8.4 |
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Table 2. Average computation time, accuracy, and average error of three algorithms under experimental images