A compact non-chain pulse deuterium fluoride (DF) laser renewing the working gas by axial-flow has been established. The characteristics of miniaturized axial flow non-chain pulse DF laser were studied experimentally. When the ratio of working gas SF₆∶D₂ = 10∶1 and total pressure=8 kP, the output energy of DF laser was about 800 mJ and full width at half maximum was about 120 ns at single pulse mode, which was similar to transverse flow DF laser. When working at repetition rate of 20 Hz, a maximum output power of 13.1 W was reached in this laser, whose amplitude difference of laser pulses was less than 5%. Then, the possibility of high repetition rate operation of axial flow DF laser was prospected. An axial flow non-chain pulse DF laser was proposed in this paper, which provides a new technology approach for the miniaturization and engineering application of the mid-infrared laser.