Deep learning algorithms to segment and quantify the choroidal thickness and vasculature in swept-source optical coherence tomography images

Gu Zheng; Yanfeng Jiang; Ce Shi; Hanpei Miao; Xiangle Yu; Yiyi Wang; Sisi Chen; Zhiyang Lin; Weicheng Wang; Fan Lu; Meixiao Shen

doi:10.1142/s1793545821400022

[1] M. Wang, I. C. Munch, P. W. Hasler, C. Prunte, M. Larsen, "Central serous chorioretinopathy," Acta Ophthalmol. 86, 126–145 (2008).

[2] P. Jirarattanasopa, S. Ooto, I. Nakata, A. Tsujikawa, K. Yamashiro, A. Oishi, N. Yoshimura, "Choroidal thickness, vascular hyperpermeability, and complement factor H in age-related macular degeneration and polypoidal choroidal vasculopathy," Invest. Ophthalmol. Vis. Sci. 53, 3663–3772 (2012).

[3] M. Adhi, E. Brewer, N. K. Waheed, J. S. Duker, "Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography," JAMA Ophthalmol. 131, 1267–1274 (2013).

[4] G. Yiu, S. J. Chiu, P. A. Petrou, S. Stinnett, N. Sarin, S. Farsiu, E. Y. Chew, W. T. Wong, C. A. Toth, "Relationship of central choroidal thickness with age-related macular degeneration status," Am. J. Ophthalmol. 159, 617–626 (2015).

[5] E. Tsuiki, K. Suzuma, R. Ueki, Y. Maekawa, T. Kitaoka, "Enhanced depth imaging optical coherence tomography of the choroid in central retinal vein occlusion," Am. J. Ophthalmol. 156, 543–547e1 (2013).

[6] F. Zheng, G. Gregori, K. B. Schaal, A. D. Legarreta, A. R. Miller, L. Roisman, W. J. Feuer, P. J. Rosenfeld, "Choroidal thickness and choroidal vessel density in nonexudative age-related macular degeneration using swept-source optical coherence tomography imaging," Invest Ophthalmol. Vis. Sci. 57, 6256–6264 (2016).

[7] S. Zhang, G. Zhang, X. Zhou, R. Xu, S. Wang, Z. Guan, J. Lu, N. Srinivasalu, M. Shen, Z. Jin, J. Qu, X. Zhou, "Changes in choroidal thickness and choroidal blood perfusion in Guinea Pig Myopia," Invest Ophthalmol. Vis. Sci. 60, 3074–3083 (2019).

[8] Q. Chen, F. Tan, Y. Wu, X. Zhuang, C. Wu, Y. Zhou, Y. Li, D. Cheng, J. Wang, F. Lu, M. Shen, "Characteristics of retinal structural and microvascular alterations in early type 2 diabetic patients," Invest Ophthalmol. Vis. Sci. 59, 2110–2118 (2018).

[9] X. Liu, M. Shen, S. Huang, L. Leng, D. Zhu, F. Lu, "Repeatability and reproducibility of eight macular intra-retinal layer thicknesses determined by an automated segmentation algorithm using two Sdoct instruments," PLoS One 9, e87996 (2014).

[10] Q. Chen, S. Huang, Q. Ma, H. Lin, M. Pan, X. Liu, F. Lu, M. Shen, "Ultra-high resolution profiles of macular intra-retinal layer thicknesses and associations with visual field defects in primary open angle glaucoma," Sci. Rep. 7, 41100 (2017).

[11] J. Ye, M. Shen, S. Huang, Y. Fan, A. Yao, C. Pan, X. Shi, F. Lu, Y. Shao, "Visual acuity in pathological myopia is correlated with the photoreceptor myoid and ellipsoid zone thickness and affected by choroid thickness," Invest. Ophthalmol. Vis. Sci. 60, 1714–1723 (2019).

[12] X. Liu, M. Shen, Y. Yuan, S. Huang, D. Zhu, Q. Ma, X. Ye, F. Lu, "Macular thickness profiles of intraretinal layers in myopia evaluated by ultrahighresolution optical coherence tomography," Am. J. Ophthalmol. 160, 53–61e2 (2015).

[13] V. S. Vuong, E. Moisseiev, D. Cunefare, S. Farsiu, A. Moshiri, G. Yiu, "Repeatability of choroidal thickness measurements on enhanced depth imaging optical coherence tomography using different posterior boundaries," Am. J. Ophthalmol. 169, 104– 112 (2016).

[14] Z. X. Zhang, Q. J. Liu, Y. H. Wang, "Road extraction by deep residual U-net," IEEE Geosci. Remote Sens. Lett. 15, 749–753 (2018).

[15] R. Agrawal, J. Ding, P. Sen, A. Rousselot, A. Chan, L. Nivison-Smith, X. Wei, S. Mahajan, R. Kim, C. Mishra, M. Agarwal, M. H. Suh, S. Luthra, M. R. Munk, C. Y. Cheung, V. Gupta, Cvi.grid. "Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index," Prog. Retin. Eye Res. 77, 100829 (2020).

[16] R. Agrawal, P. Gupta, K. A. Tan, C. M. Cheung, T. Y. Wong, C. Y. Cheng, "Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a populationbased study," Sci. Rep. 6, 21090 (2016).

[17] X. Wei, S. Kumar, J. Ding, N. Khandelwal, M. Agarwal, R. Agrawal, "Choroidal structural changes in smokers measured using choroidal vascularity index," Invest. Ophthalmol. Vis. Sci. 60, 1316–1320 (2019).

[18] S. Rizzo, A. Savastano, L. Finocchio, M. C. Savastano, N. Khandelwal, R. Agrawal, "Choroidal vascularity index changes after vitreomacular surgery," Acta Ophthalmol. 96, e950-e5 (2018).

[19] M. Pellegrini, G. Giannaccare, F. Bernabei, F. Moscardelli, C. Schiavi, E. C. Campos, "Choroidal vascular changes in arteritic and nonarteritic anterior ischemic optic neuropathy," Am. J. Ophthalmol. 205, 43–49 (2019).

[20] X. Wei, C. Mishra, N. B. Kannan, G. E. Holder, N. Khandelwal, R. Kim, R. Agrawal, "Choroidal structural analysis and vascularity index in retinal dystrophies," Acta Ophthalmol. 97, e116–e121 (2019).

[21] B. Lee, J. Ahn, C. Yun, S. W. Kim, J. Oh, "Variation of retinal and choroidal vasculatures in patients with age-related macular degeneration," Invest Ophthalmol. Vis. Sci. 59, 5246–5255 (2018).

[22] J. W. Shin, Y. U. Shin, B. R. Lee, "Choroidal thickness and volume mapping by a six radial scan protocol on spectral-domain optical coherence tomography," Ophthalmology 119, 1017–1123 (2012).

[23] V. Manjunath, M. Taha, J. G. Fujimoto, J. S. Duker, "Choroidal thickness in normal eyes measured using Cirrus Hd optical coherence tomography," Am. J. Ophthalmol. 150, 325–329 e1 (2010).

[24] H. Zhou, Z. Chu, Q. Zhang, Y. Dai, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Attenuation correction assisted automatic segmentation for assessing choroidal thickness and vasculature with swept-source oct," Biomed. Opt. Exp. 9, 6067–6080 (2018).

[25] L. Zhang, K. Lee, M. Niemeijer, R. F. Mullins, M. Sonka, M. D. Abramo?, "Automated segmentation of the choroid from clinical Sd-oct," Invest Ophthalmol. Vis. Sci. 53, 7510–7519 (2012).

[26] L. Duan, Y. J. Hong, Y. Yasuno, "Automated segmentation and characterization of choroidal vessels in high-penetration optical coherence tomography," Opt. Exp. 21, 15787–15808 (2013).

[27] V. Kajic, M. Esmaeelpour, C. Glittenberg, M. F. Kraus, J. Honegger, R. Othara, S. Binder, J. G. Fujimoto, W. Drexler, "Automated three-dimensional choroidal vessel segmentation of 3d 1060 Nm oct retinal data," Biomed. Opt. Exp. 4, 134–150 (2013).

[28] N. Srinath, A. Patil, V. K. Kumar, S. Jana, J. Chhablani, A. Richhariya, "Automated detection of choroid boundary and vessels in optical coherence tomography images," Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2014, 166–169 (2014).

[29] S. Masood, R. Fang, P. Li, H. Li, B. Sheng, A. Mathavan, X. Wang, P. Yang, Q. Wu, J. Qin, W. Jia, "Automatic choroid layer segmentation from optical coherence tomography images using deep learning," Sci. Rep. 9, 3058 (2019).

[30] X. D. Sui, Y. J. Zheng, B. Z. Wei, H. S. Bi, J. F. Wu, X. M. Pan, Y. L. Yin, S. T. Zhang, "Choroid segmentation from optical coherence tomography with graph edge weights learned from deep convolutional neural networks," Neurocomputing 237, 332–341 (2017).

[31] X. Liu, L. Bi, Y. Xu, D. Feng, J. Kim, X. Xu, "Robust deep learning method for choroidal vessel segmentation on swept source optical coherence tomography images," Biomed. Opt. Exp. 10, 1601– 1612 (2019).

[32] R. Agrawal, J. Chhablani, K. A. Tan, S. Shah, C. Sarvaiya, A. Banker, "Choroidal vascularity index in central serous chorioretinopathy," Retina 36, 1646–1651 (2016).

[33] S. Demirel, G. Ozcan, O. Yanik, F. Batioglu, E. Ozmert, "Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy," Graefes Arch. Clin. Exp. Ophthalmol. 257, 905–912 (2019).

[34] M. Coban-Karatas, R. Altan-Yaycioglu, B. Ulas, S. Sizmaz, H. Canan, C. Sariturk, "Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion," Int. J. Ophthalmol. 9, 725–729 (2016).

[35] K. H. Kim, D. H. Lee, J. J. Lee, S. W. Park, I. S. Byon, J. E. Lee, "Regional choroidal thickness changes in branch retinal vein occlusion with macular edema," Ophthalmologica 234, 109–118 (2015).

[36] G. Querques, R. Lattanzio, L. Querques, C. Del Turco, R. Forte, L. Pierro, E. H. Souied, F. Bandello, "Enhanced depth imaging optical coherence tomography in Type 2 diabetes," Invest Ophthalmol. Vis. Sci. 53, 6017–6024 (2012).