Chalcogenide glass lens is one of the important components for novel temperature-adaptation IR optical systems. With the development of thermal imaging civil market, the demand for industrialization technology of chalcogenide glass lens is increasing rapidly. Precision molding of As2Se3 chalcogenide glass aspheric lens were studied systematically. A series of molding process parameters were investigated and optimized for As2Se3 chalcogenide lens with a diameter of Φ21 mm. Through the compensation correction of the mould, chalcogenide lens that met the design precision of PV <0.7 μm were fabricated successfully. Effect of molding on the physical properties of As2Se3 chalcogenide glass was also investigated. The results show that after molding, the density, hardness, and glass transition temperature of As2Se3 glass decrease, whereas its maximum transmittance increases. With the help of Raman spectra, the microstructural origin of these abnormal phenomena was analyzed and discussed. This work would provide data and reference for future fabrication of large-aperture aspheric chalcogenide lens.