We present a single-mode multilayer-core fiber with a large mode area (LMA) and a low bending loss in this Letter. A low equivalent core-cladding refractive index difference is achieved by exploiting the multilayer structure. The multilayer structure has a better bending performance than a traditional step-index core and this structure also contributes to realizing different curved refractive index profiles that have a better bending performance. An index trench is also introduced to dramatically reduce the bending loss. The experimental results show that, at a wavelength of 1550 nm, the mode area of the fabricated fiber is about 215.5μm2 and the bending loss is 0.58 dB/turn at a 10 mm bending radius. The LMA and excellent bending performance can be obtained simultaneously with the proposed fiber.