The relationship between aerosol extinction coefficient and PM2.5 mass concentration is analyzed, it is proposed that the PM2.5 mass concentration profile can be retrieved by combining the side-scatter lidar system based on charge-coupled device (CCD) and PM2.5 detector. From case study, when the variation of relative humidity is small, PM2.5 mass concentration is proportional to aerosol extinction coefficient at ground. The characteristic of PM2.5 mass concentration profile of near-ground on April 13, and December 16, 2014 at Dongpu island of western suburb of Hefei city is analyzed as changing with time, changing with altitude, and air pollutant concentration is comparatively large in close surface. The experimental results show that the side-scatter lidar system based on CCD combined PM2.5 detector is an effective new method of exploring pollutant mass concentration profile in near-ground.