A nonlinear effect equation describing intra-channel four-wave mixing and intra-channel cross phase modulation in quasi-linear optical transmission system was deduced. The simulation model set for this system was built. Based on this model set, the dispersion management schemes of the quasi-linear optical transmission systems with 10 Gb/s, 40 Gb/s, 100 Gb/s and 160 Gb/s data rates were analyzed. The relationships between the amplitude jitters and the timing jitters, the amplitude jitters and the related Q values, the pulse initial powers and the related Q values were analyzed. At the first time, it’s concluded that the optimal dispersion management scheme is related to the system transmission data rate, and the ratio of the pre-dispersion component can be decreased while the post-dispersion component increase with the increasing of system data rate.