Considering that the irradiance distribution obtained by using optical fiber and fly-eye lens is of poor uniformity, methods of adding integrator rods and frosted glasses to improve the uniformity of optical fiber irradiation device are proposed. The measurement results indicate that the effect is very remarkable. The ultraviolet A (UVA) band of ultraviolet radiation is measured. The uniformity is raised from ±8.9% to ±3.5% in the irradiated area of 80 mm×80 mm after an integrator rod is added at the input end of the optical fiber. And the uniformity of the central area of 30 mm×30 mm is raised from ±3.3% to ±0.7%. On that basis, after the frosted glass is added at the input end of the fly-eye lens, its uniformity can reach ±0.6% in the central area of 30 mm×30 mm, and the UV irradiance which is eccentrically distributed becomes axially symmetrically distributed. The multiple light sources superposing methods are also put forward to improve uniformity of light source while higher irradiance is obtained at the same time. The results indicate that the irradiance and the uniformity can reach about 30 mW/cm2 and ±3.9% respectively in the irradiated area of 80 mm×80 mm by using two optical fiber irradiation devices to superpose irradiation. Using the methods of superposition of three light sources and casted by the fly-eye lens, the irradiance and the uniformity are about 60 mW/cm2 and ±2.4% respectively in the irradiated area whose diameter is 80 mm.