An intelligent control system based on STM32 is designed aimed at prominent problem of the lack of integration of the laser control system and relatively single function. The system is equipped with a human-computer interaction interface based on EMWIN, which realizes the pulse laser touch screen control. Based on the system’s high-frequency clock, multi-channel pulse width modulation signal is generated to achieve high-precision control of the pulsed laser: the pumping voltage is 0～1000 V, which enables continuous adjustment. The pulse frequency is from 1 to 200 Hz, and the adjustment of multiple gear positions can be realized. The pulse width is 0～1000 μs, which is continuously adjustable with an accuracy of 20 μs. Both voltage and pulse width adjustments support fine-tuning and coarse tuning. The temperature sensor and ultrasonic ranging module are equipped on the system to monitor the laser operating temperature and divide the safe operating area in real-time.The signal measurement module is also introduced into the system with a sampling frequency of 1 to 100 kHz. The design realizes the integration of laser control and measurement, as well as process control and safety monitoring of laser operation.