Surface plasmon resonance (SPR) sensor based on the blue phosphorene/MoS2 hetero-structure is presented to enhance the performance parameters, i.e., sensitivity, detection accuracy, and quality factor. The blue phosphorene/MoS2 hetero-structure works as an interacting layer with the analyte for the enhancement of the sensitivity of the sensor. It is observed that the sensitivity of blue phosphorene/MoS2 based sensor (i.e., structure-II) is improved by 5.75%, from the conventional sensor (i.e., structure-III). Further, an additional silicon nanolayer is introduced between the metal layer and blue phosphorene/MoS2 hetero-structure. The sensitivity of the proposed blue phosphorene/MoS2 hetero-structure with a silicon layer SPR sensor, i.e., structure-I, is enhanced by 44.76% from structure-II and 55.75% from structure-III due to an enhancement in the evanescent field near the metal-analyte interface. Finally, it is observed that at the optimum thickness of silicon between the gold layer and blue phosphorene/MoS2, performance parameters of the sensor are enhanced.