Refract optical system using in remote sensing usually has many elements,complicated structure and diffraction limited image quality,which makes the alignment puzzled.Combined with the adjustment mathematical model,the CODE V optical design software and the field interference Zernike coefficient are integrated into the alignment variables for calculating the misalignment.According to the off-axis three mirror ideal optical system model,the alignment sensitivity matrix is acquired and the correct order of multi misalignment variables is determined,which can overcome the alignment correlation effectively.It is effective and convenient to raise the optical system wavefront error root mean square (RMS) from 0.563 λ (=632.8 nm) to 0.064 λ .After the orbit test,the multi-spectral camera imaging quality is excellent.