Surface plasmon resonance sensors based on Au-metalized nanolayer in microstructured optical fibers are theoretically analyzed by using finite element method. In simulations, the accurate Drude-Lorentz model is used to describe the metal dielectric constant. The numerical results show that as the refractive index of the liquid increases, the surface plasmon resonance peak shifts to longer wavelength. The sensitivity of Au-metalized surface plasmon resonance sensor can reach 1200 nm/RIU (refractive index unit) and the corresponding resolution is 8.33×10-5 RIU.