155 Mb/s～10 Gb/s orthogonal FSK/IM signal’s transmission over 100 km of standard fiber based on mid-span spectral inversion is experimentally demonstrated. The phase-conjugation is achieved by four-wave mixing in an optimized semiconductor optical amplifier (SOA), which solves the dispersion problem of the FSK/IM orthogonal signal. We use the DFB laser as the optical source, and take the Corning’s standard single-mode fiber as transmission link, and adopt the SOA with 500 μm length, and 0.15 optical confinement factor to realize spectral inversion. In the experiment, the central wavelength of orthogonal FSK/IM signal is fixed. We get the eye diagrams of the packet (label) in the IM (FSK) receiver. The results prove that the system has a good performance.