Computer color matching has gradually become the mainstream color matching method to ensure the consistency of packaging and printing products in the color reproduction process. The basic spectrum database is the basic condition of computer color matching, and its establishment method is too complicated, which affects the promotion and application of computer color matching technology. According to Kubelka-Munk theoretical analysis, the spline mass concentration (concentration for short), ink concentration gradient, and the number of ink gradients have a great influence on the color matching results in the process of establishing the basic spectrum database. In order to optimize the basic spectral database and obtain more accurate color matching results, based on the single factor experiment method, orthogonal experiment method, and related evaluation methods, an optimal combination of concentration gradient, gradient number, and concentration range of spline ink in the process of color matching database building is proposed. In the experiment,we use the established database to match Pantone colors, calculate the color difference, and analyze the results based on the concentration range. Experimental results show that the optimized spectrum color matching database greatly reduces the workload of database construction. At the same time, the accuracy of the target color matching results obtained by calculation is high, which meets the production requirements, indicating that the method can effectively select the best parameter combination.