A radiometric calibration method is introduced by using the Moon as on-orbit calibration reference for the visible channel of geostationary remote sensing radiometer. Lunar images in FY-2E’s operational frames were collected and selected. Lunar disk-integrated irradiances were calculated for data processing. The main procedures of data processing include lunar image over-sampling correction, distance correction, and lunar phase correction. The long-term response attenuation of the visible channel of FY-2E’s radiometer was evaluated by the time trend of the sequence. The result shows that the annual attenuation rate of the visible channel of FY-2E’s radiometer is about 2.17%, which is consistent with the results of other calibration methods. The long-term response attenuation of geostationary remote sensing radiometer visible channel is well assessed by using the lunar calibration technique, providing reference for the systematic correction of the radiometric calibration of the radiometer.